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ID 109784
Title Alternative
肥満解消のための無作為介入研究による脂肪量とアディポサイトカインの変化
Author
Kawashima, Nobuhisa The University of Tokushima|Koshien University
Watanabe, Shaw Life Science Promoting Association
Morita, Akemi Koshien University
Aiba, Naomi Kanagawa Institute of Technology
Miyachi, Motohiko National Institute of Health and Nutrition
Keywords
Adiponectin
Leptin
Biomarker
RCT
obesity control
Human
Content Type
Thesis or Dissertation
Description
Adipocytokines arebioactive substances synthesizedand secretedbyfat cell. Previous studies have reported an association between weight loss and adipocytokines. However, these studies are inconsistent and they have not clarified the relationship between weight regain and changes in circulating levels of adipocytokines.
In this study, we analyzed the relationship between weight and fat volume changes and adipocytokines. The subjects were 235obese people recruited in the Saku Control Obesity Program (SCOP). Participants were randomly assigned to either immediate (Group A) or delayed (Group B, control group). Group A participants were followed for another two years after completion of the one year intervention. As controls, Group B participants received the same intervention as Group A after a delay of one year. Then they were followed up for one year. The intervention consisted in a one-year lifestyle program to induce weight loss, based on a cognitive-behavioral approach.
After the first year of the study, body weight, BMI, body fat and abdominal fat areas were significantly lower in group A participants, compared to controls. After the intervention, leptin levels were significantly lowered both in men and women. After one year follow-up, both men and women re-gained about 1.5 kg body weight on average. BMI, waist circumference, fat areas by CT and HBA1c significantly increased during the follow-up period. The change of adipocytokine levels by analysis of the quartile of body weight decrease and regain revealed that increased adiponectin and decreased leptin was noteworthy for weight reduction, while increase of leptin influenced the weight regain.
In conclusion, our results suggest that leptin could have broad effects on the distribution off at tissues and on lipid metabolism. Leptin inversely associated with adiponectin, which in turn was necessary to decrease body weight. In particular, leptin decreased remarkably in the process of weight reduction, and its increase seemed to be related in weight regain. The observed increase of adiponectin seemed to be induced by reduction in fat volume.
Journal Title
Diabetes Research : Open Journal
ISSN
23796375
Publisher
Openventio Publishers
Volume
1
Issue
5
Start Page
136
End Page
146
Published Date
2016-01-28
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201608021002.pdf
論文本文 : LID201608021003.pdf
本論文は, 著者Nobuhisa Kawashimaの学位論文として提出され, 学位審査・授与の対象となっている。
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2961号
Diploma Number
甲栄第236号
Granted Date
2016-06-23
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences