Total for the last 12 months
number of access : ?
number of downloads : ?
ID 110148
Author
Hamada, Junichi Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
Shoda, Katsutoshi Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
Masuda, Kiyoshi Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School KAKEN Search Researchers
Fujita, Yuji Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
Naruto, Takuya Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School KAKEN Search Researchers
Kohmoto, Tomohiro Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Student Lab, Tokushima University Faculty of Medicine
Miyakami, Yuko Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Student Lab, Tokushima University Faculty of Medicine
Watanabe, Miki Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Student Lab, Tokushima University Faculty of Medicine
Kudo, Yasusei Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Fujiwara, Hitoshi Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
Ichikawa, Daisuke Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
Otsuji, Eigo Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
Imoto, Issei Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School KAKEN Search Researchers
Keywords
T-cell intracellular antigen-1
isoform
oncogene
RNA-binding protein
esophageal squamous cell carcinoma
Content Type
Journal Article
Description
T-cell intracellular antigen-1 (TIA1) is an RNA-binding protein involved in many regulatory aspects of mRNA metabolism. Here, we report previously unknown tumor-promoting activity of TIA1, which seems to be associated with its isoform-specific molecular distribution and regulation of a set of cancer-related transcripts, in esophageal squamous cell carcinoma (ESCC). Immunohistochemical overexpression of TIA1 ectopically localized in the cytoplasm of tumor cells was an independent prognosticator for worse overall survival in a cohort of 143 ESCC patients. Knockdown of TIA1 inhibited proliferation of ESCC cells. By exogenously introducing each of two major isoforms, TIA1a and TIA1b, only TIA1a, which was localized to both the nucleus and cytoplasm, promoted anchorage-dependent and anchorage-independent ESCC cell proliferation. Ribonucleoprotein immunoprecipitation, followed by microarray analysis or massive-parallel sequencing, identified a set of TIA1-binding mRNAs, including SKP2 and CCNA2. TIA1 increased SKP2 and CCNA2 protein levels through the suppression of mRNA decay and translational induction, respectively. Our findings uncover a novel oncogenic function of TIA1 in esophageal tumorigenesis, and implicate its use as a marker for prognostic evaluation and as a therapeutic target in ESCC.
Journal Title
Oncotarget
ISSN
19492553
Volume
7
Issue
13
Start Page
17111
End Page
17128
Sort Key
17111
Published Date
2016-03-06
Remark
Copyright: © 2016 Masuda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source arecredited.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
Oral Sciences