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ID 115632
Author
Furukawa, Koichi Chubu University|Nagoya University
Ohmi, Yuhsuke Chubu University
Yesmin, Farhana Chubu University|Nagoya University
Tajima, Orie Chubu University
Kondo, Yuji Nagoya University
Zhang, Pu Chubu University|Nagoya University
Ohkawa, Yuki Osaka International Cancer Institute
Bhuiyan, Robiul H. Chubu University
Furukawa, Keiko Chubu University
Keywords
ganglioside
knockout
neurodegeneration
glycosphingolipid
inflammation
microdomain
Content Type
Journal Article
Description
Acidic glycosphingolipids, i.e., gangliosides, are predominantly and consistently expressed in nervous tissues of vertebrates at high levels. Therefore, they are considered to be involved in the development and function of nervous systems. Recent studies involving genetic engineering of glycosyltransferase genes have revealed novel aspects of the roles of gangliosides in the regulation of nervous tissues. In this review, novel findings regarding ganglioside functions and their modes of action elucidated mainly by studies of gene knockout mice are summarized. In particular, the roles of gangliosides in the regulation of lipid rafts to maintain the integrity of nervous systems are reported with a focus on the roles in the regulation of neuro-inflammation and neurodegeneration via complement systems. In addition, recent advances in studies of congenital neurological disorders due to genetic mutations of ganglioside synthase genes and also in the techniques for the analysis of ganglioside functions are introduced.
Journal Title
International Journal of Molecular Sciences
ISSN
14220067
16616596
NCID
AA12038549
Publisher
MDPI
Volume
21
Issue
6
Start Page
1906
Published Date
2020-03-11
Rights
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version)
URL ( Publisher's Version )
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language
eng
TextVersion
Publisher
departments
Oral Sciences