ID | 115632 |
Author |
Furukawa, Koichi
Chubu University|Nagoya University
Ohmi, Yuhsuke
Chubu University
Yesmin, Farhana
Chubu University|Nagoya University
Tajima, Orie
Chubu University
Kondo, Yuji
Nagoya University
Zhang, Pu
Chubu University|Nagoya University
Hashimoto, Noboru
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Ohkawa, Yuki
Osaka International Cancer Institute
Bhuiyan, Robiul H.
Chubu University
Furukawa, Keiko
Chubu University
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Keywords | ganglioside
knockout
neurodegeneration
glycosphingolipid
inflammation
microdomain
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Content Type |
Journal Article
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Description | Acidic glycosphingolipids, i.e., gangliosides, are predominantly and consistently expressed in nervous tissues of vertebrates at high levels. Therefore, they are considered to be involved in the development and function of nervous systems. Recent studies involving genetic engineering of glycosyltransferase genes have revealed novel aspects of the roles of gangliosides in the regulation of nervous tissues. In this review, novel findings regarding ganglioside functions and their modes of action elucidated mainly by studies of gene knockout mice are summarized. In particular, the roles of gangliosides in the regulation of lipid rafts to maintain the integrity of nervous systems are reported with a focus on the roles in the regulation of neuro-inflammation and neurodegeneration via complement systems. In addition, recent advances in studies of congenital neurological disorders due to genetic mutations of ganglioside synthase genes and also in the techniques for the analysis of ganglioside functions are introduced.
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Journal Title |
International Journal of Molecular Sciences
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ISSN | 14220067
16616596
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NCID | AA12038549
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Publisher | MDPI
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Volume | 21
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Issue | 6
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Start Page | 1906
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Published Date | 2020-03-11
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Rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version) | |
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language |
eng
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TextVersion |
Publisher
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departments |
Oral Sciences
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