ID | 111177 |
Title Alternative | 脳腫瘍における動脈スピンラベリング法及び多変量ダイナミック磁化率コントラスト灌流MRI法の比較
ASL and DSC MRI of brain tumors
|
Author |
Khashbat, Delgerdalai
Tokushima University
Ganbold, Mungunbagana
Tokushima University
Uyama, Naoto
Tokushima University
Irahara, Saho
Tokushima University
Otomi, Youichi
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
|
Keywords | magnetic resonance imaging
arterial spin labeling
dynamic susceptibility contrast perfusion
time to maximum
brain tumor
|
Content Type |
Thesis or Dissertation
|
Description | Purpose : Arterial spin labeling (ASL) is an alternative method to Dynamic susceptibility contrast (DSC) perfusion MRI for brain tumors. However, ASL cerebral blood flow (CBF) can be easily affected by transit time. DSC MRI derived time to maximum of the residue function (Tmax) is possible to assess the transit time on ASL. Methods : Thirty patients with brain tumors were studied using ASL and DSC MRI. The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), Tmax, and mean transit time (MTT) were obtained from DSC MRI. The ratios of the parameters were analyzed. Results : ASL CBF ratio correlated with the DSC rCBF ratio (r=0.78, p<0.001) and rCBV ratio (r=0.74, p<0.001). There was a moderate correlation between ASL CBF ratio and Tmax ratio (r=-0.43, p<0.05) in brain tumors. Conclusions : ASL CBF strongly correlated with DSC rCBF and rCBV. In addition, a negative correlation was found between ASL CBF and Tmax in brain tumors, indicating that these parameters would be affected by transit time. This may explain why ASL CBF is different from DSC rCBF and rCBV. The decreased DSC Tmax value may suggest high vascularity in a tumor.
|
Journal Title |
The Journal of Medical Investigation
|
ISSN | 13496867
13431420
|
NCID | AA11166929
AA12022913
|
Publisher | Faculty of Medicine Tokushima University
|
Volume | 63
|
Issue | 3-4
|
Start Page | 175
|
End Page | 181
|
Sort Key | 175
|
Published Date | 2016-08
|
Remark | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606101003.pdf 論文本文 : LID201609291002.pdf 本論文は,著者Delgerdalai Khashbatの学位論文として提出され,学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
ETD
|
MEXT report number | 甲第2956号
|
Diploma Number | 甲医第1289号
|
Granted Date | 2016-03-23
|
Degree Name |
Doctor of Medical Science
|
Grantor |
Tokushima University
|
departments |
Medical Sciences
University Hospital
|