ID | 109666 |
Title Alternative | 血清I型コラーゲンC末端テロペプチド濃度は心血管リスクを有する患者の頚動脈硬化と関連する
ICTP as a marker for atherosclerosis
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Author |
Aihara, Ken-ichi
Tokushima University
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Onishi, Yukiyo
Tokushima University
Dong, Bingzi
Tokushima University
Ohguro, Yukari
Tokushima University
Yoshida, Sumiko
Tokushima University
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Fujinaka, Yuichi
Tokushima Prefecture Naruto Hospital
Kuroda, Akio
Tokushima University
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Matsuhisa, Munehide
Tokushima University
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Matsumoto, Toshio
Tokushima University
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Abe, Masahiro
Tokushima University
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Keywords | ICTP
Atherosclerosis
Max IMT
baPWV
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Content Type |
Thesis or Dissertation
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Description | Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macrophages led to the hypothesis that serum ICTP concentrations may serve as a non-invasive clinical biomarker for atherosclerosis. Therefore, the association of serum ICTP concentrations with the maximum intima-media thickness (IMT) of carotid arteries, a surrogate index of systemic atherosclerosis, or brachial-ankle pulse wave velocity (baPWV) in patients with atherosclerotic risk factors was evaluated. A total of 52 male and 65 female (mean age: 62.8 yrs) patients without renal failure, malignancies or bone diseases known to affect serum ICTP concentrations were recruited. Patients with max IMTs ≥1.1 mm showed significantly higher serum ICTP concentrations compared with patients with max IMTs <1.1 mm (3.33 ± 0.97 vs 2.82 ± 0.65 ng/mL, p<0.05). Serum ICTP concentration was also positively correlated with max IMT (p<0.001) or baPWV values (p<0.05). Multivariate analyses also revealed that serum ICTP concentrations were correlated with max IMT (p<0.001; 95% CI 0.200 to 0.454). These results suggest that serum ICTP concentrations can be used as a non-invasive biomarker for systemic atherosclerosis.
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Journal Title |
Endocrine Journal
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ISSN | 13484540
09188959
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NCID | AA12020190
AA10901436
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Publisher | 一般社団法人 日本内分泌学会
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Volume | 63
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Issue | 4
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Start Page | 397
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End Page | 404
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Published Date | 2016-04-25
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Remark | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201605311001.pdf 論文本文 : LID201605311002.pdf 本論文は, 著者Takeshi Kondoの学位論文として提出され, 学位審査・授与の対象となっている。 公開に関する許諾確認は著者・編集事務局間のメールによる |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第2904号
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Diploma Number | 甲医第1278号
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Granted Date | 2016-03-07
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
University Hospital
Medical Sciences
Institute of Advanced Medical Sciences
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