ID | 116739 |
Author |
Higashikuni, Yasutomi
The University of Tokyo
Liu, Wenhao
The University of Tokyo
Obana, Takumi
The University of Tokyo
Sata, Masataka
The University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
|
Keywords | COVID-19
endothelial injury
inflammation
platelet activation
SARS-CoV-2
therapeutics
thrombosis
|
Content Type |
Journal Article
|
Description | Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with a great impact on social and economic activities, as well as public health. In most patients, the symptoms of COVID-19 are a high-grade fever and a dry cough, and spontaneously resolve within ten days. However, in severe cases, COVID-19 leads to atypical bilateral interstitial pneumonia, acute respiratory distress syndrome, and systemic thromboembolism, resulting in multiple organ failure with high mortality and morbidity. SARS-CoV-2 has immune evasion mechanisms, including inhibition of interferon signaling and suppression of T cell and B cell responses. SARS-CoV-2 infection directly and indirectly causes dysregulated immune responses, platelet hyperactivation, and endothelial dysfunction, which interact with each other and are exacerbated by cardiovascular risk factors. In this review, we summarize current knowledge on the pathogenic basis of thromboinflammation and endothelial injury in COVID-19. We highlight the distinct contributions of dysregulated immune responses, platelet hyperactivation, and endothelial dysfunction to the pathogenesis of COVID-19. In addition, we discuss potential therapeutic strategies targeting these mechanisms.
|
Journal Title |
International Journal of Molecular Sciences
|
ISSN | 14220067
|
Publisher | MDPI
|
Volume | 22
|
Issue | 21
|
Start Page | 12081
|
Published Date | 2021-11-08
|
Rights | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
|
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
Publisher
|
departments |
Medical Sciences
|