ID | 113418 |
Title Alternative | DOACs for ProteinS deficiency
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Author |
Yagi, Shusuke
Tokushima University
Tokushima University Educator and Researcher Directory
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Sata, Masataka
Tokushima University
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Keywords | VTE
apixavan
congenital thrombophilia
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Content Type |
Journal Article
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Description | Protein S (PS) deficiency is an inherited thrombophilia associated with an increased risk of venous thromboembolism (VTE). In Japan, unfractionated heparin followed by warfarin has been historically applied for the treatment of VTE. Recent evidence showed that direct oral anticoagulants (DOACs) were non-inferior to standard therapy with warfarin, with significantly less bleeding in patients with VTE. However, it is unknown whether DOACs are effective for the treatment of VTE in patients with thrombophilia, including protein S deficiency, due to lack of evidence. Here, we report a case of recurrent venous thrombosis during edoxaban therapy in a patient with protein S deficiency, which was successfully treated using high-dose apixaban therapy.
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Journal Title |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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NCID | AA12022913
AA11166929
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Publisher | Tokushima University Faculty of Medicine
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Volume | 66
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Issue | 1-2
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Start Page | 182
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End Page | 184
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Sort Key | 182
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Published Date | 2019-02
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
University Hospital
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