ID | 109609 |
Title Transcription | イショセイ シボウ ト 2ガタ トウニョウビョウ シンゾウ ケッカンビョウ
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Title Alternative | Ectopic fat deposition, type 2 diabetes mellitus and cardiovascular diseases
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Author |
Shimabukuro, Michio
Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences|Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
Dagvasumberel, Munkhbaatar
Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
Ishida, Masayoshi
Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
Matsumoto, Sachiko
Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
Kozuka, Chisayo
Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
Taira, Shin-ichiro
Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
Yabiku, Kouichi
Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
Yagi, Shusuke
Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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Fukuda, Daiju
Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences|Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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Yamada, Hirotsugu
Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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Soeki, Takeshi
Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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Wakatsuki, Tetsuzo
Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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Oyadomari, Seiichi
Division of Molecular Biology, Institute for Genome Research, the University of Tokushima
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Masuzaki, Hiroaki
Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
Sata, Masataka
Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
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Keywords | Ectopic fat deposition
Diabetes mellitus
Cardiovascular diseases
Obesity
Metabolic syndrome
Lipotoxicity
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Content Type |
Journal Article
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Description | There is evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as the metabolic syndrome (MetS). Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in the liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. In addition, ectopic fat deposition play a critical role in the heart components such as (1) circulatory and locally recruited fat, (2) intra-and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is discussed via possible mechanisms including adipocytokine, insulin resistance and lipotoxicity.
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Journal Title |
四国医学雑誌
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ISSN | 00373699
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NCID | AN00102041
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Publisher | 徳島医学会
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Volume | 69
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Issue | 1-2
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Start Page | 21
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End Page | 28
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Sort Key | 21
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Published Date | 2013-04-25
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EDB ID | |
FullText File | |
language |
jpn
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TextVersion |
Publisher
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departments |
Medical Sciences
University Hospital
Institute of Advanced Medical Sciences
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