ID | 112321 |
Title Alternative | Gender and coronary artery bypass graft surgery
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Author |
Maimaituxun, Gulinu
Tokushima University
Salim, Hotimah Masdan
Tokushima University
Tabata, Minoru
Sakakibara Heart Institute
Yuji, Daisuke
Shonan-Kamakura General Hospital
Morimoto, Yoshihisa
Awaji Medical Center
Akasaka, Takeshi
Shonan-Kamakura General Hospital
Matsuura, Tomomi
Tokushima University
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Yagi, Shusuke
Tokushima University
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Yamada, Hirotsugu
Tokushima University
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Soeki, Takeshi
Tokushima University
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Sugimoto, Takaki
Awaji Medical Center
Tanaka, Masashi
Shonan-Kamakura General Hospital
Takanashi, Shuichiro
Sakakibara Heart Institute
Sata, Masataka
Tokushima University
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Content Type |
Journal Article
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Description | Background
Traditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown. Methods Gender-linked impact of EATV, abdominal fat distribution and other traditional ASCVD risk factors were compared in 172 patients (men: 115; women: 57) who underwent CABG or non-coronary valvular surgery (non-CABG). Results In men, EATV, EATV index (EATV/body surface area) and the markers of adiposity such as body mass index, waist circumference and visceral fat area were higher in the CABG group than in the non-CABG group. Traditional ASCVD risk factors were also prevalent in the CABG group. In women, EATV and EATV index were higher in the CABG group, but other adiposity markers were comparable between CABG and non-CABG groups. Multivariate logistic regression analysis showed that in men, CABG was determined by EATV Index and other ASCVD risk factors including hypertension, dyslipidemia, adiponectin, high sensitive C-reactive protein (hsCRP) and type 2 diabetes mellitus (Corrected R2 = 0.262, p < 0.0001), while in women, type 2 diabetes mellitus is a single strong predictor for CABG, excluding EATV Index (Corrected R2 = 0.266, p = 0.005). Conclusions Our study found that multiple risk factors, including epicardial adipose tissue volume and traditional ASCVD factors are determinants for CABG in men, but type 2 diabetes mellitus was the sole determinant in women. Gender-specific disparities in risk factors of CABG prompt us to evaluate new diagnostic and treatment strategies and to seek underlying mechanisms. |
Journal Title |
PLOS ONE
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ISSN | 19326203
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Publisher | PLOS
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Volume | 12
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Issue | 6
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Start Page | e0177170
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Published Date | 2017-06-08
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Rights | Copyright: © 2017 Maimaituxun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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DOI (Published Version) | |
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language |
eng
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Publisher
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departments |
Medical Sciences
University Hospital
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