ID | 106069 |
Title Alternative | 肝細胞癌の肝内再発における非癌部でのCD44発現の役割
CD44 expression in HCC
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Author |
Tovuu, Lkhagva-Ochir
The University of Tokushima
Morine, Yuji
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Ikemoto, Tetsuya
The University of Tokushima
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Mori, Hiroki
The University of Tokushima
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Hanaoka, Jun
The University of Tokushima
Sugimoto, Koji
The University of Tokushima
Saito, Yu
The University of Tokushima
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Yamada, Shinichiro
The University of Tokushima
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Asanoma, Michihito
The University of Tokushima
Miyake, Hidenori
The University of Tokushima
Shimada, Mitsuo
The University of Tokushima
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Keywords | hepatocellular carcinoma
CD44
prognostic factor
non tumor tissue
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Content Type |
Thesis or Dissertation
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Description | Background: CD44 is well known to be one of the cancer stem cell markers and is a cell-surface glycoproteininvolved in cell-cell interactions, cell adhesion, and cell migration. We investigated the role of CD44 expression in both tumor and non-tumor tissues on recurrence of hepatocellular carcinoma (HCC).
Methods: Forty-eight patients with HCC who underwent hepatic resection at our institution were enrolled in this study. CD44 expressions in both tumor and non-tumor tissues were examined using real time reverse transcription-polymerase chain reaction. The patients were divided into two groups: high and low gene-expression group, based on the CD44 expression level. We compared the clinicopathological factors between the high expression and low expression groups in both tumor and non-tumor tissues. Results: In the tumor tissues, the gene-expression levels of CD44 did not correlate with any clinicopathological parameters. The disease-free survival rate showed no significant difference between the two gourps. In non-tumor tissues, although there was no significant relationship between the CD44 expression levels and clinicopathological factors, disease-free survival rate in the CD44 low expression group was significantly better than that in the CD44 high expression group (p<0.05). In multivariate analysis, the risk factors in tumor recurrence were presence of microscopic portal invasion and high expression level of CD44. Conclusion: The CD44 expressions in the non-tumor tissues may predict HCC recurrence. |
Journal Title |
International Journal of Clinical Oncology
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ISSN | 13419625
14377772
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NCID | AA11086579
AA11625629
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Publisher | Springer nature
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Volume | 18
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Issue | 4
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Start Page | 651
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End Page | 656
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Published Date | 2012-06-16
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Remark | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201404221013.pdf 論文本文 : LID201410281001.pdf 本論文は, 著者Lkhagva-Ochir Tovuuの学位論文として提出され, 学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第2669号
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Diploma Number | 甲医第1189号
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Granted Date | 2014-03-24
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
University Hospital
Medical Sciences
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