ID | 110346 |
Title Transcription | ショウカキガン ニオケル HIF-1 ノ リンショウテキ イギ ト チリョウ エノ オウヨウ
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Title Alternative | Clinical significance and therapeutic implication of Hypoxia Inducible Factor-1(HIF-1) expression in gastrointestinal cancer
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Author |
Utsunomiya, Tohru
Department of Digestive Surgery and Transplantation, Tokushima University Hospital|Cancer Management Center, Tokushima University Hospital
Shimada, Mitsuo
Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School
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Imura, Satoru
Department of Digestive Surgery and Transplantation, Tokushima University Hospital
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Morine, Yuji
Department of Digestive Surgery and Transplantation, Tokushima University Hospital
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Ikemoto, Tetsuya
Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School
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Hanaoka, Jhun
Department of Digestive Surgery and Transplantation, Tokushima University Hospital
Mori, Hiroki
Department of Digestive Surgery and Transplantation, Tokushima University Hospital
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Kanamoto, Mami
Department of Digestive Surgery and Transplantation, Tokushima University Hospital
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Iwahashi, Shuichi
Department of Digestive Surgery and Transplantation, Tokushima University Hospital
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Saito, Yu
Department of Digestive Surgery and Transplantation, Tokushima University Hospital
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Yamada, Shinichiro
Department of Digestive Surgery and Transplantation, Tokushima University Hospital
Asanoma, Michihito
Department of Digestive Surgery and Transplantation, Tokushima University Hospital
Miyake, Hidenori
Department of Digestive Surgery and Transplantation, Tokushima University Hospital
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Keywords | hypoxia inducible factor‐1
histone deacetylase
epigenetics
cancer stem cell
epithelial-mesenchymal transition
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Content Type |
Journal Article
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Description | Hypoxia inducible factor‐1α(HIF‐1α)and histone deacetylase(HDAC)expressions in gastrointestinal cancer, especially intrahepatic cholangiocarcinoma and pancreas cancer, significantly reflect on the malignant potential of these cancers, and are significantly associated with patient’s prognosis. It has also been shown that HIF‐1α is deacetylated and stabilized by nucleosome remodeling and histone deacetylation (NuRD) complex, consisting of HDAC and metastasis-associated gene‐1(MTA1), leading to angiogenesis. More recently, it has been reported that HIF‐1α induces tumorigenesis and ultimately cancer stemness through epithelial-mesenchymal transition (EMT). Therefore, HIF‐1α may be one of the master molecules of cancer progression, and it is expected that novel therapeutic strategies will be devised by controlling the signaling pathway of HIF‐1α in hypoxic condition of gastrointestinal cancer.
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Journal Title |
四国医学雑誌
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ISSN | 00373699
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NCID | AN00102041
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Publisher | 徳島医学会
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Volume | 67
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Issue | 1-2
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Start Page | 15
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End Page | 20
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Sort Key | 15
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Published Date | 2011-04-25
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EDB ID | |
FullText File | |
language |
jpn
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TextVersion |
Publisher
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departments |
Medical Sciences
University Hospital
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