ID | 110757 |
Author |
Nagano, Takamasa
Division of Psychiatry, Hosogi Unity Hospital
Matsuda, Yukihiko
Division of Internal Medicine, Hosogi Unity Hospital
Tanioka, Tetsuya
Department of Community and Psychiatric Nursing, School of Medical Sciences, The University of Tokushima
Tokushima University Educator and Researcher Directory
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Yoshioka, Takaoki
Division of Psychiatry, Hosogi Unity Hospital
Hiroi, Tadashi
Division of Psychiatry, Hosogi Unity Hospital
Yoshikawa, Kenichi
Division of Psychiatry, Hosogi Unity Hospital
Okabe, Ken-ichiro
Division of Psychiatry, Hosogi Unity Hospital
Osaka, Kyoko
Department of Community and Psychiatric Nursing, School of Medical Sciences, The University of Tokushima
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Nagamine, Isao
Department of Community and Psychiatric Nursing, School of Medical Sciences, The University of Tokushima
Takasaka, Yoichiro
Division of Psychiatry, Hosogi Unity Hospital
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Keywords | schizophrenia
β 3-adrenergic receptor polymorphism
obesity
metabolic disease
Trp 64 Arg allele
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Content Type |
Journal Article
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Description | This study was conducted to address the question of whether the β3-adrenergic receptor gene mutation (Trp 64 Arg) is associated with metabolic disease in Japanese patients with schizophrenia. Methods : In a cross-sectional study, 89 participants were grouped into three genotypes. The 64 Arg allelic frequency in patients with or without metabolic disease was analyzed. Anthropometrics variables and biochemical parameters were compared among the genotypes. Results : The 64 Arg allele, which had a frequency of 0.22, was not associated with obesity, type 2 diabetes mellitus, dyslipidemias, or hypertension. No significant differences among the genotypes were found in current age, age at diagnosis with schizophrenia, body mass index, waist-hip ratio, plasma glucose, plasma insulin, triglycerides, free fatty acids. Patients with the 64 Arg allele had greater 24-h excretion of norepinephrine than those lacking the variant (p=0.019). Conclusion : The 64Arg allelic mutation is not associated with obesity, type 2 diabetes mellitus, lipid metabolism dysfunction, or hypertension in Japanese patients with schizophrenia.
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Journal Title |
The journal of medical investigation : JMI
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ISSN | 13431420
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NCID | AA11166929
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Volume | 52
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Issue | 1-2
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Start Page | 57
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End Page | 64
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Sort Key | 57
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Published Date | 2005-02
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
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