ID | 111266 |
Title Alternative | 2型糖尿病患者における非侵襲的皮下自家蛍光測定の動脈硬化の代替指標としての有用性の検証
Skin Autofluorescence and Atherosclerosis
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Author |
Temma, Jin
Tokushima University
Matsuhisa, Munehide
Tokushima University
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Horie, Toru
Tenma Hospital
Kuroda, Akio
Tokushima University
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Mori, Hiroyasu
Tokushima University
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Endo, Itsuro
Tokushima University
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Aihara, Ken-ichi
Tokushima University
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Abe, Masahiro
Tokushima University
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Keywords | skin autofluorescence
intima-media thickness
type 2 diabetes
atherosclerosis
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Content Type |
Thesis or Dissertation
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Description | Advanced glycation end-products (AGEs) are thought to play a major role in the pathogenesis of diabetic vascular complications. Skin autofluorescence (AF) was recently reported to represent tissue AGEs accumulation with a non-invasive method. The aim of the present study was to evaluate association between AF value and diabetic vascular complications, such as retinopathy, nephropathy and cervical atherosclerosis using the carotid intima-media thickness (IMT), an established marker of cardiovascular disease in patients with type 2 diabetes. A total of 68 patients with type 2 diabetes were enrolled in a cross-sectional manner. AGEs accumulation was measured with AF reader. Clinical parameters were collected at the time of AF and IMT measurement. Max-IMT was correlated with age and AF (r=0.407, p=0.001), but not with HbA1c, GA, and pentosidine. Also, AF was not correlated with HbA1c, GA and pentosidine, but was correlated with age (r=0.560, p<0.001), duration of diabetes (r=0.256, p<0.05). Multivariate regression analysis revealed that AF, but not age, was an independent determinant of max-IMT. In conclusion, AF might be a beneficial surrogate marker for evaluating carotid atherosclerosis in patients with type 2 diabetes non-invasively.
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Journal Title |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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NCID | AA11166929
AA12022913
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Publisher | Faculty of Medicine Tokushima University
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Volume | 62
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Issue | 3-4
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Start Page | 126
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End Page | 129
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Sort Key | 126
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Published Date | 2015-08
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Remark | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201505211009.pdf 論文本文 : LID201505211010.pdf 本論文は,著者Jin Temmaの学位論文として提出され,学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第2803号
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Diploma Number | 甲医第1245号
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Granted Date | 2015-03-19
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
Institute of Advanced Medical Sciences
Medical Sciences
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