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ID 117529
Title Alternative
ヒト白血病K562細胞におけるアドリアマイシン作用のクレモフォールELによる修飾
Author
Matsui, Hiroko The University of Tokushima
Sakanashi, Yoko The University of Tokushima
Nishimura, Yumiko The University of Tokushima
Horimoto, Kanna The University of Tokushima
Kanemaru, Kaori The University of Tokushima KAKEN Search Researchers
Ishida, Shiro Tokushima Bunri University
Okano, Yoshiro Tokushima Bunri University
Oyama, Yasuo The University of Tokushima KAKEN Search Researchers
Keywords
adriamycin
cremophor EL
cytotoxicity
human leukemia K562 cells
Content Type
Departmental Bulletin Paper
Description
Adriamycin and paclitaxel are simultaneously used for cancer treatment in some cases. The formula of paclitaxel contains cremophor EL as a solvent. Since this solvent exerts diverse biological actions, the modification of adriamycin action by cremophor EL has been studied on human leukemia K562 cells. Cremophor EL did not significantly affect the concentration-response relation for antiproliferative action of adriamycin and the cell cycle changed by adriamycin. However, the induction of morphological change by adriamycin was significantly augmented by cremophor EL. The simultaneous application of cremophor EL increased the intensity of fluorescence from adriamycin trapped inside the cells in a concentration-dependent manner, suggesting an increase in intracellular concentration of adriamycin by cremophor EL. Adriamycin alone at concentrations higher than those to completely inhibit the growth induced morphological change in K562 cells. Therefore, cremophor EL may potentiate some of actions induced by adriamycin when adriamycin and paclitaxel are simultaneously applied.
Journal Title
Natural Science Research
ISSN
09146385
NCID
AN10065859
Publisher
徳島大学総合科学部
Volume
21
Start Page
9
End Page
17
Sort Key
9
Published Date
2007-12-21
EDB ID
FullText File
nsr_21_9.pdf 1.51 MB
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry