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ID 118610
Title Alternative
Systemic amyloidosis by LPL
Author
Hori, Taiki Anan Medical Center|Tokushima University
Yasui, Saya Anan Medical Center
Hosoki, Minae Anan Medical Center
Otoda, Toshiki Tokushima University
Takishita, Makoto Anan Medical Center
Yokohama, Akihiko Gunma University
Ueda, Mitsuharu Kumamoto University
Keywords
lymphoplasmacytic lymphoma
amyloidosis
rituximab
Content Type
Journal Article
Description
We present the case of an 81-year-old woman with right shoulder discomfort and right supraclavicular lymph node swelling who referred to our hospital. Blood tests results showed normal immunoglobulin levels, but free light chain assay showed abnormal κ/λ ratio. Serum immunoelectrophoresis detected immunoglobulin G-λ type M proteins. 18F-fluorodeoxyglucose computed tomography revealed swelling of the right supraclavicular and mediastinal lymph nodes. Biopsy of the right supraclavicular lymph node showed a mixture of small lymphocytes with plasma cell-like round cells that were positive for cell surface CD20, CD138, CD56, IgG and λ, and negative for transthyretin and amyloid A. They had a Congo red stain-positive, glass-like surrounding structure and apple-green birefringence was observed under polarized light. Duodenal, gastric, and skin biopsies also showed amyloid deposits. We diagnosed the patient with lymphoplasmacytic lymphoma complicated by systemic light-chain amyloidosis. Rituximab monotherapy led to complete metabolic response. Systemic amyloidosis is a rare complication of B-cell lymphoma; however, the possibility of amyloidosis should be considered, even in patients with lymphadenopathy.
Journal Title
International Journal of Myeloma
ISSN
21873143
NCID
AA12766965
Publisher
Japanese Society of Myeloma
Volume
13
Issue
2
Start Page
7
End Page
12
Published Date
2023
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences