ID | 118625 |
Author |
Azuma, Momoyo
Tokushima University
Tokushima University Educator and Researcher Directory
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Oishi, Kazunori
Toyama Institute of Health
Akeda, Yukihiro
National Institute of Infectious Diseases|Osaka University
Morino, Saeko
National Institute of Infectious Diseases
Motoki, Yumi
Hakuai Memorial Hospital
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Keywords | Sequential administration
13-valent pneumococcal conjugate vaccine
23-valent pneumococcal polysaccharide
vaccine
Safety
Immunogenicity
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Content Type |
Journal Article
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Description | Objective: An open-label study was conducted to compare the safety and immunogenicity of a sequential administration of 13-valent pneumococcal conjugate vaccine (PCV13) followed by 23-valent pneumococcal polysaccharide vaccine (PPSV23) between an interval of 0.5 (0.5-y) and 1 year (1.0-y) in adults aged ≥ 65 years.
Methods: Pneumococcal vaccine-naïve adults aged ≥ 65 years (n = 129) received a sequential administration with an interval of 0.5-y or 1.0-y or received a single administration of PPSV23 (single PPSV23). We evaluated the immunogenicity before and 1 month after each vaccination and at 0.5-y intervals for 2 years. The primary endpoint was the increase in geometric mean fold rises (GMFRs) of immunoglobulin G (IgG) or opsonophagocytic activity (OPA) for eight common serotypes one month after one dose of PPSV23. The secondary endpoint was the safety profile for one dose of PPSV23. Results: One month after administration of PPSV23, the GMFRs of IgG considerably increased for five of eight serotypes in the 1.0-y interval group, whereas the GMFRs of IgG considerably increased for two serotypes in the 0.5-y interval group. Furthermore, GMFRs of OPA markedly increased for all eight serotypes in the 1.0-y interval group, while GMFRs of OPA markedly increased for four serotypes in the 0.5-y interval group. At 2 years after initial vaccination, GMFRs of IgG or OPA were higher for all serotypes, except for serotype 3, than those in the single PPSV23 group irrespective of intervals. No significant difference was found in the frequencies of local reactions of all grades between the two intervals. Conclusions: The 1.0-y interval provided better booster effects induced by PPSV23 than those of the 0.5-y interval in a sequential administration in pneumococcal vaccine-naïve adults aged ≥ 65 years. No difference was found in the safety profile between both intervals. |
Journal Title |
Vaccine
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ISSN | 0264410X
18732518
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NCID | AA11541256
AA10491877
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Publisher | Elsevier
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Volume | 41
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Issue | 5
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Start Page | 1042
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End Page | 1049
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Published Date | 2022-12-31
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Rights | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
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language |
eng
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TextVersion |
Publisher
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departments |
University Hospital
Medical Sciences
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