ID | 112399 |
Author |
Numata, Shusuke
Tokushima University
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Yamamori, Hidenaga
Osaka University
Yasuda, Yuka
Osaka University
Fujimoto, Michiko
Osaka University
Umehara, Hidehiro
Tokushima University
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Shimodera, Shinji
Kochi Medical School
Nakazawa, Takanobu
Osaka University
Kikuchi, Masataka
Osaka University
Nakaya, Akihiro
Osaka University
Hashimoto, Hitoshi
Osaka University
Hashimoto, Ryota
Osaka University
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Keywords | schizophrenia
DNA methylation
clozapine
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Content Type |
Journal Article
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Description | Clozapine is an atypical antipsychotic, that is established as the treatment of choice for treatment-resistant schizophrenia (SCZ). To date, no study investigating comprehensive DNA methylation changes in SCZ patients treated with chronic clozapine has been reported. The purpose of the present study is to reveal the effects of clozapine on DNA methylation in treatment-resistant SCZ. We conducted a genome-wide DNA methylation profiling in peripheral leukocytes (485,764 CpG dinucleotides) from treatment-resistant SCZ patients treated with clozapine (n = 21) in a longitudinal study. Significant changes in DNA methylation were observed at 29,134 sites after one year of treatment with clozapine, and these genes were enriched for “cell substrate adhesion” and “cell matrix adhesion” gene ontology (GO) terms. Furthermore, DNA methylation changes in the CREBBP (CREB binding protein) gene were significantly correlated with the clinical improvements. Our findings provide insights into the action of clozapine in treatment-resistant SCZ.
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Journal Title |
International Journal of Molecular Sciences
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ISSN | 14220067
16616596
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NCID | AA12038549
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Publisher | MDPI
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Volume | 18
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Issue | 3
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Start Page | 632
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Published Date | 2017-03-14
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Rights | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version) | |
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language |
eng
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TextVersion |
Publisher
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departments |
University Hospital
Medical Sciences
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