ID | 114688 |
Title Alternative | Successful cord blood cell transplantation in a patient with refractory hepatosplenic T-cell lymphoma
臍帯血移植が奏効した肝脾型T細胞リンパ腫
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Author |
Fujii, Shiro
Tokushima University
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Takahashi, Mamiko
Tokushima University
Nakamura, Shingen
Tokushima University
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Abe, Masahiro
Tokushima University
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Inoue, Yusuke
Tokushima University
Ikegame, Akishige
Tokushima University
Miki, Hirokazu
Tokushima University
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Keywords | Hepatosplenic T-cell lymphoma
refractory
cord blood transplantation
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Content Type |
Journal Article
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Description | Cord blood for transplant is collected from the umbilical cord and donated cord blood is tested, frozen and stored for future use. Cord blood stem cell transplantation(CBT)do not have to be as closely matched as bone marrow or peripheral blood stem cell transplantations, therefore we are able to perform CBT for refractory patients at optimal timing. Here, we report a 33 years old woman with refractory hepatosplenic T-cell lymphoma(HSTL)who achieved complete response ; CR after unrelated CBT. She complained of fever and abdominal pain, she was diagnosed with HSTL. She was refractory to several chemotherapy regimens, we planned to allogenic transplantation for her. However, she had no HLA-matched sibling donors and we were not able to find favorable unrelated donors from Japan Marrow Donor Program. Therefore, we decided to perform CBT for her. We used fludarabine(180mg/m2), busulfan(12.8mg/kg)and melphalan(80mg/m2) as conditioning regimens and we chose tacrolimus and MMF for graft versus host disease(GVHD) prophylaxis. On day 22 after transplantation, her neutrophil count engrafted, she suffered from acute GVHD(skin, gastrointestinal tract, grade2), she was improved by medical treatment. She achieved CR her disease status maintained over two years after CBT. HSTL is often refractory to chemotherapy, the clinical efficacy of hematopoietic stem cell transplantation may be expected. Our case suggests that CBT may be effective and feasible option for refractory HSTL who has no favorable HLA-matched donors.
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Journal Title |
Shikoku Acta Medica
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ISSN | 00373699
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NCID | AN00102041
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Publisher | 徳島医学会
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Volume | 75
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Issue | 5-6
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Start Page | 221
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End Page | 226
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Sort Key | 221
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Published Date | 2019-12-25
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FullText File | |
language |
jpn
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TextVersion |
Publisher
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departments |
University Hospital
Medical Sciences
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