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ID 118015
Author
Minato, Masanori Tokushima University
Murakami, Taichi Tokushima University|Ehime Prefectural Central Hospital KAKEN Search Researchers
Takahashi, Naoki University of Fukui
Ono, Hiroyuki Tokushima University
Nishimura, Kenji Tokushima University
Iwano, Masayuki University of Fukui
Joh, Kensuke The Jikei University School of Medicine
Keywords
tubulointerstitial nephritis with IgM-positive plasma cells
intracellular crystalline inclusions in the rough endoplasmic reticulum
glucocorticoid dependence
Content Type
Journal Article
Description
Tubulointerstitial nephritis (TIN) with IgM-positive plasma cells (IgMPC-TIN) is an autoimmune kidney disease characterized by IgM/CD138-double-positive plasma cell infiltration in the tubulointerstitium. A 50-year-old man developed IgMPC-TIN and presented with crystalline inclusions in the rough endoplasmic reticulum. Intracellular crystal formation is a rare finding in paraprotein-related kidney diseases, but this case showed no pathogenic monoclonal immunoglobulin. Prednisolone (PSL, 30 mg) improved the TIN, but PSL tapering resulted in the recurrence of TIN. Combination therapy with 15 mg PSL and 150 mg mizoribine ultimately stabilized TIN. This case offers original evidence concerning the pathophysiology and treatment strategy of IgMPC-TIN.
Journal Title
Internal Medicine
ISSN
13497235
Publisher
The Japanese Society of Internal Medicine
Volume
60
Issue
19
Start Page
3129
End Page
3136
Published Date
2021-10-01
Rights
The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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DOI (Published Version)
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language
eng
TextVersion
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departments
Medical Sciences
University Hospital