ID | 118015 |
Author |
Minato, Masanori
Tokushima University
Takahashi, Naoki
University of Fukui
Ono, Hiroyuki
Tokushima University
Nishimura, Kenji
Tokushima University
Iwano, Masayuki
University of Fukui
Joh, Kensuke
The Jikei University School of Medicine
Doi, Toshio
Tokushima University
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Keywords | tubulointerstitial nephritis with IgM-positive plasma cells
intracellular crystalline inclusions in the rough endoplasmic reticulum
glucocorticoid dependence
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Content Type |
Journal Article
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Description | Tubulointerstitial nephritis (TIN) with IgM-positive plasma cells (IgMPC-TIN) is an autoimmune kidney disease characterized by IgM/CD138-double-positive plasma cell infiltration in the tubulointerstitium. A 50-year-old man developed IgMPC-TIN and presented with crystalline inclusions in the rough endoplasmic reticulum. Intracellular crystal formation is a rare finding in paraprotein-related kidney diseases, but this case showed no pathogenic monoclonal immunoglobulin. Prednisolone (PSL, 30 mg) improved the TIN, but PSL tapering resulted in the recurrence of TIN. Combination therapy with 15 mg PSL and 150 mg mizoribine ultimately stabilized TIN. This case offers original evidence concerning the pathophysiology and treatment strategy of IgMPC-TIN.
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Journal Title |
Internal Medicine
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ISSN | 13497235
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Publisher | The Japanese Society of Internal Medicine
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Volume | 60
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Issue | 19
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Start Page | 3129
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End Page | 3136
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Published Date | 2021-10-01
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Rights | The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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language |
eng
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Publisher
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departments |
Medical Sciences
University Hospital
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