ID | 110846 |
Author |
Tanimoto, Shuji
Department of Urology, Takamatsu Red Cross Hospital
Fukumori, Tomoharu
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
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El-Moula, Gad
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Shiirevnyamba, Avirmed
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Kinouchi, Shinichiro
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Koizumi, Takahiro
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Nakanishi, Ryoichi
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Yamamoto, Yasuyo
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Taue, Ryuichi
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Yamaguchi, Kunihisa
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Nakatsuji, Hiroyoshi
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Kishimoto, Tomoteru
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Izaki, Hirofumi
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Oka, Natsuo
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Takahashi, Masayuki
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Kanayama, Hiro-omi
Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Keywords | renal cell carcinoma
hepatocyte growth factor
vascular endothelial growth factor
prognostic maker
diagnostic maker
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Content Type |
Journal Article
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Description | No adequate serum predictive biomarker currently exists, which can identify the activity of renal cell carcinoma (RCC). We investigate the association of serum hepatocyte growth factor (HGF) and serum vascular endothelial growth factor (VEGF) levels with clinicopathologic parameters in untreated clear cell RCC patients. We measured serum levels of HGF and VEGF in 45 patients with untreated clear cell RCC and 45 healthy controls using an enzyme-linked immunosorbent assay (ELISA). Patients with clear cell RCC had significantly higher serum HGF and VEGF concentrations than healthy subjects : median, 1070.7 versus 728.3 pg/ml (p<0.0001) for HGF and median, 397.5 versus 245.6 pg/ml (p=0.0003) for VEGF. We found a significant correlation between serum level of HGF and clinical stage and tumor grade. Survival of patients with high serum HGF (>1150 pg/ml) was significantly reduced compared to patients with low serum HGF concentrations (p=0.0044). In patients with nuclear grade 2 or high stage RCC, the higher serum HGF group exhibited significantly lower cause-specific survival (p= 0.0087 and p<0.05, respectively). No significant difference was observed between serum VEGF levels and cause-specific survival rate. Serum HGF might be a diagnostic and prognostic indicator in clear cell RCC, especially for patients with grade 2 or high stage RCC.
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Journal Title |
The journal of medical investigation : JMI
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ISSN | 13431420
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NCID | AA11166929
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Volume | 55
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Issue | 1-2
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Start Page | 106
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End Page | 111
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Sort Key | 106
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Published Date | 2008-02
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
University Hospital
Medical Sciences
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