ID | 110842 |
Author |
Kawanaka, Takashi
Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Kubo, Akiko
Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Ikushima, Hitoshi
Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Sano, Toshiaki
Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Takegawa, Yoshihiro
Department of Radiologic Technology, School of Health Sciences, The University of Tokushima
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Nishitani, Hiromu
Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School
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Keywords | hypoxia
HIF-2 alpha
macrophage
uterine cervical cancer
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Content Type |
Journal Article
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Description | Hypoxia-inducible factor (HIF)-2α, a basic helix-loop-helix (bHLH)-PAS protein, is the principal regulator of the hypoxic transcriptional response. An immunohistochemical study reported strong HIF-2α expression in the cytoplasm of tumor infiltrative macrophages (TIMs). Thus we assessed the expression of HIF-2α in human cervical cancer tissue before radiation therapy and its relationship to the clinical outcome. Seventy three patients with histologically proven primary advanced squamous cell carcinoma of the uterine cervix underwent radiotherapy in Tokushima University Hospital after biopsy specimens were taken. Among 73 specimens stained for HIF-2α, 53 (72.6%) exhibited HIF-2α immunoreactivity in the TIMs. In only 5 of 73 cases, HIF-2α immunoreactivity was observed in the nuclei of tumor cells. The HIF-2αpositive cell count ratio in TIMs was associated with disease-free survival (DFS) with the worst DFS (p=0.024) being in cases in the group with a high positive cell count ratio. A high HIF-2α positive cell count ratio in TIMs increased the risk of local recurrence (p=0.0142). These findings might suggest that the ratio of the HIF-2α positive cell in TIMs may be a new predictive indicator for prognosis before radiation therapy for uterine cervical cancer.
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Journal Title |
The journal of medical investigation : JMI
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ISSN | 13431420
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NCID | AA11166929
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Volume | 55
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Issue | 1-2
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Start Page | 78
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End Page | 86
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Sort Key | 78
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Published Date | 2008-02
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
University Hospital
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