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ID 118315
Title Alternative
食餌性リンはマウスの腸内環境を変化させる
Author
Oda, Naoko Tokushima University
Sugihara, Kohei Tokushima University
Ohnishi, Kohta Tokushima University
Keywords
hyperphosphatemia
microbiota
chronic kidney disease
tight junction
short chain fatty acids
Content Type
Thesis or Dissertation
Description
Disorder of phosphate metabolism is a common pathological condition in chronic kidney disease patients. Excessive intake of dietary phosphate deteriorates chronic kidney disease and various complications including cardiovascular and infectious diseases. Recent reports have demonstrated that gut microbiome disturbance is associated with both the etiology and progression of chronic kidney disease. However, the relationship between dietary phosphate and gut microbiome remains unknown. Here, we examined the effects of excessive intake of phosphate on gut microbiome. Five-week-old male C57BL/6J mice were fed either control diet or high phosphate diet for eight weeks. Analysis of the gut microbiota was carried out using MiSeq next generation sequencer, and short-chain fatty acids were determined with GC-‍MS. In analysis of gut microbiota, significantly increased in Erysipelotrichaceae and decreased in Ruminococcaceae were observed in high phosphate diet group. Furthermore, high phosphate diet induced reduction of microbial diversity and decreased mRNA levels of colonic tight junction markers. These results suggest that the excessive intake of dietary phosphate disturbs gut microbiota and affects intestinal barrier function.
Journal Title
Journal of Clinical Biochemistry and Nutrition
ISSN
09120009
18805086
NCID
AA10710201
Publisher
Society for Free Radical Research Japan
Volume
73
Issue
3
Start Page
221
End Page
227
Published Date
2023-11-01
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Naoko Odaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3732号
Diploma Number
甲栄第297号
Granted Date
2023-03-24
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences