ID | 105887 |
Title Alternative | 日本人における魚介類摂取頻度、血清肝機能酵素とPFOS、PFOAの血液中濃度
Seafood, Serum Liver Enzymes, PFOS and PFOA in Blood
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Author |
Yamaguchi, Miwa
Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
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Arisawa, Kokichi
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Katuura-Kamano, Sakurako
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Takami, Hidenobu
The University of Tokushima
Sawachika, Fusakazu
The University of Tokushima
Nakamoto, Mariko
The University of Tokushima
Tokushima University Educator and Researcher Directory
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Juta, Tomoya
The University of Tokushima
Toda, Eisaku
Ministry of the Environment of Japan
Mori, Kei
Ministry of the Environment of Japan
Hasegawa, Manabu
Ministry of the Environment of Japan
Tanto, Masaharu
Ministry of the Environment of Japan
Shima, Masayuki
Ministry of the Environment of Japan
Sumiyoshi, Yoshio
Ministry of the Environment of Japan
Kodama, Kazunori
Ministry of the Environment of Japan
Suzuki, Takaichiro
Ministry of the Environment of Japan
Nagai, Masaki
Ministry of the Environment of Japan
Satoh, Hiroshi
Ministry of the Environment of Japan
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Keywords | Blood
Fish intake
Perfluorooctanesulfonate (PFOS)
Perfluorooctanoate (PFOA)
Serum liver enzymes
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Content Type |
Thesis or Dissertation
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Description | Objective: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) have been shown to accumulate in the human body. The purpose of the present study was to examine the factors associated with the blood levels of PFOS and PFOA. Methods: A cross-sectional study was performed on 307 men and 301 women (aged 16−76 years) living in 15 prefectures in Japan. Blood levels of PFOS and PFOA were measured by liquid chromatography-mass spectrometry. Hepatic enzymes (γ-GTP, GOT, and GPT) and ω-3 polyunsaturated fatty acids (DHA and EPA) levels in serum were also measured. Associations between the levels of PFOS and PFOA in blood and the intake frequency of 41 kinds of dishes, foods and beverages and the serum levels of liver enzymes and ω-3 polyunsaturated fatty acids were examined using rank correlations. Results: Frequency of intake of boiled fish in broth, sliced raw fish and coastal fish showed significant positive correlations with PFOS concentrations in blood after adjustments for potential confounders. Serum levels of GOT, GPT, DHA and EPA showed significant positive correlations with PFOS and PFOA in blood. There was also a significant regional difference in the blood levels of PFOS and PFOA, with medians being highest in the Tokai/Hokuriku/Kinki region. Conclusions: These findings suggest that the concentrations of PFOS in blood were mainly associated with fish consumption and that the levels of PFOS and PFOA were associated with the serum levels of liver enzymes in Japanese populations. Further investigations are required to clarify the reason for the regional differences in blood levels of PFOS and PFOA in Japan.
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Journal Title |
Journal of Occupational Health
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ISSN | 13489585
13419145
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NCID | AA11090645
AA11510660
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Publisher | Japan Society for Occupational Health|Wiley
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Volume | 55
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Issue | 3
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Start Page | 184
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End Page | 194
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Published Date | 2013-04-09
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Remark | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201308190002.pdf 論文本文 : LID201405230001.pdf 本論文は, 著者Miwa Yamaguchiの学位論文として提出され, 学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第2617号
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Diploma Number | 甲医第1162号
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Granted Date | 2013-05-23
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
Medical Sciences
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