ID | 115662 |
Author |
Nanri, Hinako
Showa University
Nishida, Yuichiro
Saga University
Nakamura, Kazuyo
St. Mary’s College
Tanaka, Keitaro
Saga University
Naito, Mariko
Nagoya University
Yin, Guang
Seinan Jo Gakuin University
Hamajima, Nobuyuki
Nagoya University
Takashima, Naoyuki
Shiga University of Medical Science
Suzuki, Sadao
Nagoya City University
Nindita, Yora
Kagoshima University
Kohno, Michiko
Kyushu University
Koyama, Teruhide
Kyoto Prefectural University of Medicine
Hosono, Satoyo
Aichi Cancer Center Research Institute
Mikami, Haruo
Chiba Cancer Center
Kubo, Michiaki
RIKEN
Tanaka, Hideo
Aichi Cancer Center Research Institute
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Keywords | dietary pattern
factor analysis
β-adrenergic receptor (ADRβ)
polymorphism
triglyceride
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Content Type |
Journal Article
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Description | Interactions between dietary patterns and 2 β-adrenergic receptor (ADRβ) gene polymorphisms (ADRβ2 Gln27Glu and ADRβ3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35–69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADRβ3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADRβ polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADRβ3 polymorphism modifies the effects of the bread pattern on triglyceride levels.
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Journal Title |
Nutrients
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ISSN | 20726643
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Publisher | MDPI
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Volume | 8
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Issue | 9
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Start Page | 545
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Published Date | 2016-09-06
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Rights | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version) | |
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language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
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