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ID 117974
Title Alternative
Effect of ipragliflozin on carotid intima-media thickness in type 2 diabetes patients
Author
Tanaka, Atsushi Saga University
Okada, Yosuke University of Occupational and Environmental Health
Teragawa, Hiroki JR Hiroshima Hospital
Eguchi, Kazuo Saitama Red Cross Hospital
Shimabukuro, Michio Fukushima Medical University KAKEN Search Researchers
Taguchi, Isao Dokkyo Medical University
Matsunaga, Kazuo Imari-Arita Kyoritsu Hospital
Kanzaki, Yumiko Osaka Medical and Pharmaceutical University
Yoshida, Hisako Osaka Metropolitan University
Ishizu, Tomoko University of Tsukuba
Ueda, Shinichiro University of the Ryukyus
Kitakaze, Masafumi Hanwa Daini Senboku Hospital
Murohara, Toyoaki Nagoya University
Node, Koichi Saga University
Keywords
Atherosclerosis
Carotid intima-media thickness
Ipragliflozin
Type 2 diabetes
Content Type
Journal Article
Description
Aims
To examine the effects of a 24-month treatment with ipragliflozin on carotid intima-media thickness (IMT) in type 2 diabetes patients.
Methods and results
In this multicenter, prospective, randomized, open-label, and blinded-endpoint investigator-initiated clinical trial, adults with type 2 diabetes and haemoglobin A1C (HbA1c) of 6.0–10.0% (42–86 mmol/mol) were randomized equally to ipragliflozin (50 mg daily) and non-sodium-glucose cotransporter-2 (SGLT2) inhibitor use of standard-care (control group) for type 2 diabetes and were followed-up to 24 months. The primary endpoint was the change in mean common carotid artery IMT (CCA-IMT) from baseline to 24 months. A total of 482 patients were equally allocated to the ipragliflozin (N = 241) and control (N = 241) groups, and 464 patients (median age 68 years, female 31.7%, median type 2 diabetes duration 8 years, median HbA1c 7.3%) were included in the analyses. For the primary endpoint, the changes in the mean CCA-IMT from baseline to 24 months were 0.0013 [95% confidence interval (CI), −0.0155–0.0182] mm and 0.0015 (95% CI, −0.0155–0.0184) mm in the ipragliflozin and control groups, respectively, with an estimated group difference (ipragliflozin-control) of −0.0001 mm (95% CI, −0.0191–0.0189; P = 0.989). A group difference in HbA1c change at 24 months was also non-significant between the treatment groups [−0.1% (95% CI, −0.2–0.1); P = 0.359].
Conclusion
Twenty-four months of ipragliflozin treatment did not affect carotid IMT status in patients with type 2 diabetes recruited in the PROTECT study, relative to the non-SGLT2 inhibitor-use standard care for type 2 diabetes.
Journal Title
European Heart Journal - Cardiovascular Pharmacotherapy
ISSN
20556845
Publisher
Oxford University Press|European Society of Cardiology
Volume
9
Issue
2
Start Page
165
End Page
172
Published Date
2022-10-29
Rights
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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language
eng
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departments
Medical Sciences