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ID 116689
Author
Yamasaki, Yuki Tokushima University
Takeo, Jiro Nippon Suisan Kaisha
Miyahara, Hiroko Nippon Suisan Kaisha
Sebe, Mayu Tokushima University
Bando, Masahiro Tokushima University
Tanba, Yousuke Tokushima University
Mishima, Yuna Tokushima University
Takeji, Kana Tokushima University
Ueshima, Nanako Tokushima University
Masumoto, Saeko Tokushima University
Yoshimoto, Ryoko Tokushima Prefectural Industrial Technology Centre
Tsutsumi, Yasuo M Hiroshima University
Content Type
Journal Article
Description
Fish oil-derived long-chain monounsaturated fatty acids (LCMUFAs) with a carbon chain length longer than 18 units ameliorate cardiovascular risk in mice. In this study, we investigated whether LCMUFAs could improve endothelial functions in mice and humans. In a double-blind, randomized, placebo-controlled, parallel-group, multi-center study, healthy subjects were randomly assigned to either an LCMUFA oil (saury oil) or a control oil (olive and tuna oils) group. Sixty subjects were enrolled and administrated each oil for 4 weeks. For the animal study, ApoE−/− mice were fed a Western diet supplemented with 3% of either gadoleic acid (C20:1) or cetoleic acid (C22:1) for 12 weeks. Participants from the LCMUFA group showed improvements in endothelial function and a lower trimethylamine-N-oxide level, which is a predictor of coronary artery disease. C20:1 and C22:1 oils significantly improved atherosclerotic lesions and plasma levels of several inflammatory cytokines, including IL-6 and TNF-α. These beneficial effects were consistent with an improvement in the gut microbiota environment, as evident from the decreased ratio of Firmicutes and/ or Bacteroidetes, increase in the abundance of Akkermansia, and upregulation of short-chain fatty acid (SCFA)-induced glucagon-like peptide-1 (GLP-1) expression and serum GLP-1 level. These data suggest that LCMUFAs alter the microbiota environment that stimulate the production of SCFAs, resulting in the induction of GLP-1 secretion. Fish oil-derived long-chain monounsaturated fatty acids might thus help to protect against cardiovascular disease.
Journal Title
Translational Research
ISSN
19315244
NCID
AA12149426
AA12796875
Publisher
Elsevier
Volume
237
Start Page
16
End Page
30
Published Date
2021-03-26
Rights
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences