ID | 116689 |
Author |
Tsutsumi, Rie
Tokushima University
Tokushima University Educator and Researcher Directory
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Yamasaki, Yuki
Tokushima University
Takeo, Jiro
Nippon Suisan Kaisha
Miyahara, Hiroko
Nippon Suisan Kaisha
Sebe, Mayu
Tokushima University
Bando, Masahiro
Tokushima University
Tanba, Yousuke
Tokushima University
Mishima, Yuna
Tokushima University
Takeji, Kana
Tokushima University
Ueshima, Nanako
Tokushima University
Masumoto, Saeko
Tokushima University
Yoshimoto, Ryoko
Tokushima Prefectural Industrial Technology Centre
Tsutsumi, Yasuo M
Hiroshima University
Aihara, Ken-ichi
Tokushima University
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Sata, Masataka
Tokushima University
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Content Type |
Journal Article
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Description | Fish oil-derived long-chain monounsaturated fatty acids (LCMUFAs) with a carbon chain length longer than 18 units ameliorate cardiovascular risk in mice. In this study, we investigated whether LCMUFAs could improve endothelial functions in mice and humans. In a double-blind, randomized, placebo-controlled, parallel-group, multi-center study, healthy subjects were randomly assigned to either an LCMUFA oil (saury oil) or a control oil (olive and tuna oils) group. Sixty subjects were enrolled and administrated each oil for 4 weeks. For the animal study, ApoE−/− mice were fed a Western diet supplemented with 3% of either gadoleic acid (C20:1) or cetoleic acid (C22:1) for 12 weeks. Participants from the LCMUFA group showed improvements in endothelial function and a lower trimethylamine-N-oxide level, which is a predictor of coronary artery disease. C20:1 and C22:1 oils significantly improved atherosclerotic lesions and plasma levels of several inflammatory cytokines, including IL-6 and TNF-α. These beneficial effects were consistent with an improvement in the gut microbiota environment, as evident from the decreased ratio of Firmicutes and/ or Bacteroidetes, increase in the abundance of Akkermansia, and upregulation of short-chain fatty acid (SCFA)-induced glucagon-like peptide-1 (GLP-1) expression and serum GLP-1 level. These data suggest that LCMUFAs alter the microbiota environment that stimulate the production of SCFAs, resulting in the induction of GLP-1 secretion. Fish oil-derived long-chain monounsaturated fatty acids might thus help to protect against cardiovascular disease.
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Journal Title |
Translational Research
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ISSN | 19315244
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NCID | AA12149426
AA12796875
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Publisher | Elsevier
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Volume | 237
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Start Page | 16
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End Page | 30
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Published Date | 2021-03-26
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Rights | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
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