ID | 114726 |
Title Alternative | リン負荷指数は、食事性リン負荷の新たな評価指標である : 食品を用いたアプローチ
PHOSPHATEMIC INDEX EVALUATES PHOSPHORUS LOAD
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Author |
Narasaki, Yoko
Tokushima University|Japan Society for the Promotion of Science
Yamasaki, Michiyo
Tokushima University
Matsuura, Sayaka
Tokushima University
Morinishi, Mayumi
Tokushima University
Nakagawa, Tomomi
Tokushima University
Matsuno, Mami
Tokushima University
Katsumoto, Misaki
Tokushima University
Nii, Sachi
Tokushima University
Fushitani, Yuka
Tokushima University
Sugihara, Kohei
Tokushima University
Noda, Tsuneyuki
Otsuka Pharmaceutical Co., Ltd
Yoneda, Takeshi
Otsuka Pharmaceutical Co., Ltd|Kio University
Masuda, Masashi
Tokushima University
Tokushima University Educator and Researcher Directory
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Takeda, Eiji
Tokushima University
Tokushima University Educator and Researcher Directory
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Keywords | Phosphatemix Index
Dietary phosphorus bioavailability
Crossover study
Whole-foods approach
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Content Type |
Thesis or Dissertation
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Description | Objective: Dietary phosphorus (P) restriction is crucial to treat hyperphosphatemia and reduce cardiovascular disease risk and mortality in patients with chronic kidney disease (CKD) and the wider population. Various methods for dietary P restriction exist, but the bioavailability of P in food should also be considered when making appropriate food choices to maintain patients’ quality of life. Here, we propose the ‘‘Phosphatemic Index’’ (PI) as a novel tool for evaluating dietary P load based on P bioavailability; we also evaluated the effect of continuous intake of different PI foods in mixed meals on serum intact fibroblast growth factor 23 concentration.
Design and Methods: A 2-stage crossover study was conducted: Study 1: 20 healthy participants consumed 10 different foods containing 200 mg of P, and the PI was calculated from the area under the curve of a time versus serum P concentration curve; Study 2: 10 healthy participants consumed 4 different test meals (low, medium, or high PI meals or a control) over a 5-day period. Results: Study 1 showed milk and dairy products had high PI values, pork and ham had medium PI values, and soy and tofu had low PI values. In Study 2, ingestion of high PI test meals showed higher fasting serum intact fibroblast growth factor 23 levels and lower serum 1,25-dihydroxyvitamin D levels compared with ingestion of low PI test meals. Conclusion: These findings suggest that the PI can usefully evaluate the dietary P load of various foods and may help to make appropriate food choices for dietary P restriction in CKD patients. |
Journal Title |
Journal of Renal Nutrition
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ISSN | 10512276
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NCID | AA10814783
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Publisher | Elsevier|National Kidney Foundation
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Volume | 30
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Issue | 6
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Start Page | 493
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End Page | 502
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Published Date | 2020-08-07
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yoko Narasakiの学位論文として提出され, 学位審査・授与の対象となっている。 |
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3417号
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Diploma Number | 甲栄第278号
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Granted Date | 2020-03-23
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Degree Name |
Doctor of Nutritional Science
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Grantor |
Tokushima University
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departments |
Medical Sciences
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