ID | 109976 |
Title Alternative | 食事中のリンが糖代謝および脂質代謝における効果
PHOSPHATE REGULATES GLUCOSE AND LIPID METABOLISM
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Author |
Abuduli, Maerjianghan
Tokushima University
Otani, Tamaki
Tokushima University
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Ueda, Haruka
Tokushima University
Masuda, Masashi
Tokushima University
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Sakaue, Hiroshi
Tokushima University
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Takeda, Eiji
Tokushima University
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Keywords | Brown adipose tissue
dietary phosphate
energy metabolism
visceral fat
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Content Type |
Thesis or Dissertation
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Description | Recent epidemiological and animal studies have suggested that excess intake of phosphate (Pi) is a risk factor for the progression of chronic kidney disease and its cardiovascular complications. However, little is known about the impact of dietary high Pi intake on the development of metabolic disorders such as obesity and type 2 diabetes. In this study, we investigated the effects of dietary Pi on glucose and lipid metabolism in healthy rats. Male 8-wk-old Sprague-Dawley rats were divided into three groups and given experimental diets containing varying amounts of Pi, i.e., 0.2 [low Pi (LP)], 0.6 [control Pi (CP)], and 1.2% [high Pi (HP)]. After 4 wk, the HP group showed lower visceral fat accumulation compared with other groups, accompanied by a low respiratory exchange ratio (V˙ CO2/V˙ O2) without alteration of locomotive activity. The HP group had lower levels of plasma insulin and nonesterified fatty acids. In addition, the HP group also showed suppressed expression of hepatic lipogenic genes, including sterol regulatory element-binding protein-1c, fatty acid synthase, and acetyl-CoA carboxylase, whereas there was no difference in hepatic fat oxidation among the groups. On the other hand, uncoupling protein (UCP) 1 and peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1α) expression were significantly increased in the brown adipose tissue (BAT) of the HP group. Our data demonstrated that a high-Pi diet can negatively regulate lipid synthesis in the liver and increase mRNA expression related to lipid oxidation and UCP1 in BAT, thereby preventing visceral fat accumulation. Thus, dietary Pi is a novel metabolic regulator.
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Journal Title |
American Journal of Physiology-Endocrinology and Metabolism
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ISSN | 01931849
15221555
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NCID | AA00066467
AA12004897
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Publisher | The American Physiological Society
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Volume | 310
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Issue | 7
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Start Page | E526
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End Page | E538
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Published Date | 2016-01-19
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Remark | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201611301001.pdf 論文本文:LID201611301002.pdf 本論文は, 著者Maerjianghan Abuduliの学位論文として提出され, 学位審査・授与の対象となっている。 著者の名「瑪尓江汗」の正式な漢字については審査要旨のpdfをご参照ください。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第2993号
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Diploma Number | 甲栄第238号
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Granted Date | 2016-09-29
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Degree Name |
Doctor of Nutritional Science
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Grantor |
Tokushima University
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departments |
Medical Sciences
Advance Radiation Research, Education, and Management Center
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