ID | 113364 |
Title Alternative | グレリンの脳室内投与はラットにおいて回転カゴ運動を減少させる
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Author |
Miyatake, Yumiko
Tokushima University
Shiuchi, Tetsuya
Tokushima University
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Mawatari, Kazuaki
Tokushima University
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Toda, Satomi
Tokushima University
Taniguchi, Yasuko
Tokushima University
Futami, Akari
Tokushima University
Sato, Fukiko
Tokushima University
Sebe, Mayu
Tokushima University
Tsutsumi, Rie
Tokushima University
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Minokoshi, Yasuhiko
National Institute for Physiological Sciences
Kitamura, Tadahiro
Gunma University
Gotoh, Koro
Oita University
Ueno, Masaki
Kagawa University
Nakaya, Yutaka
Tokushima University
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Keywords | Ghrelin
Voluntary exercise
Central nervous system
SPORTS rat
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Content Type |
Thesis or Dissertation
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Description | There is an increasing interest in elucidating the molecular mechanisms by which voluntary exercise is regulated. In this study, we examined how the central nervous system regulates exercise. We used SPORTS rats, which were established in our laboratory as a highly voluntary murine exercise model. SPORTS rats showed lower levels of serum ghrelin compared with those of the parental line of Wistar rats. Intrac-erebroventricular and intraperitoneal injection of ghrelin decreased wheel-running activity in SPORTS rats. In addition, daily injection of the ghrelin inhibitor JMV3002 into the lateral ventricles of Wistar rats increased wheel-running activity. Co-administration of obestatin inhibited ghrelin-induced increases in food intake but did not inhibit ghrelin-induced suppression of voluntary exercise in rats. Growth hormone secretagogue receptor (GHSR) in the hypothalamus and hippocampus of SPORTS rats was not difference that in control rats. We created an arcuate nucleus destruction model by administering monosodium glutamate (MSG) to neonatal SPORTS rats. Injection of ghrelin into MSG-treated rats decreased voluntary exercise but did not increase food intake, suggesting that wheel-running activity is not controlled by the arcuate nucleus neurons that regulate feeding. These results provide new insights into the mechanism by which ghrelin regulates voluntary activity independent of arcuate nucleus neurons.
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Journal Title |
Peptides
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ISSN | 01969781
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NCID | AA10617807
AA11536405
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Publisher | Elsevier Inc.
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Volume | 87
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Start Page | 12
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End Page | 19
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Published Date | 2016-11-05
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Yumiko Miyatakeの学位論文として提出され,学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3274号
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Diploma Number | 甲栄第263号
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Granted Date | 2019-03-22
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Degree Name |
Doctor of Nutritional Science
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Grantor |
Tokushima University
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departments |
Medical Sciences
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