ID | 116294 |
Author |
Sogabe, Masahiro
Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
Tokushima University Educator and Researcher Directory
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Okahisa, Toshiya
Tokushima University|Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
Tokushima University Educator and Researcher Directory
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Kurihara, Takeshi
Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
Kagawa, Miwako
Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers
Kagemoto, Kaizo
Tokushima University
Kida, Yoshifumi
Tokushima University
Tokushima University Educator and Researcher Directory
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Tomonari, Tetsu
Tokushima University
Tokushima University Educator and Researcher Directory
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Okamoto, Koichi
Tokushima University
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Miyamoto, Hiroshi
Tokushima University
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Nakasono, Masahiko
Tsurugi Municipal Handa Hospital
|
Keywords | metabolic syndrome
erosive esophagitis
metabolite analysis
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Content Type |
Journal Article
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Description | Background: Erosive esophagitis (EE) is strongly associated with metabolic syndrome (MS), but is not always recognized in individuals with MS and the prevalence of EE in individuals with non-MS is not low.
Aim: To examine the differences in clinical factors associated with EE at various stages of MS, as well as the differences in metabolites between subjects with MS, with and without EE. Methods: A total of 7,097 persons who underwent health checkups including esophagogastroduodenoscopy were analyzed. We examined the differences in clinical factors for EE among subjects with non-MS, pre-MS, and MS and compared metabolites between 34 subjects with MS, with and without EE. Results: EE prevalence was significantly higher in the MS and pre-MS groups than in the non-MS group (p < 0.001). EE severity was higher in the MS group than in the pre-MS and non-MS groups (p < 0.001). In the non-MS group, there were significant differences between subjects with and without EE with respect to Helicobacter pylori (H. pylori) and smoking. In the pre-MS and MS groups, there were significant differences in H. pylori, hiatal hernia, and drinking in those with and without EE. The levels of glutamine, hypoxanthine, and lactic acid metabolites were significantly different between subjects with MS, with and without EE (all p < 0.05). Conclusion: Although H. pylori and lifestyle factors such as smoking and drinking are important for EE, differences in these factors should be considered at various stages of MS. Additionally, several metabolites may be involved in the development of EE in MS. |
Journal Title |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
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ISSN | 11787007
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Publisher | Dove Medical Press
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Volume | 14
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Start Page | 1589
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End Page | 1600
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Published Date | 2021-04-12
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Rights | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
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language |
eng
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Publisher
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departments |
Medical Sciences
University Hospital
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