ID | 116931 |
Title Alternative | Gastric cancer with autoimmune gastritis
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Author |
Muguruma, Naoki
Tokushima University
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Okamoto, Koichi
Tokushima University
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Kagemoto, Kaizo
Tokushima University
Kida, Yoshifumi
Tokushima University
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Ueda, Hiroyuki
Tokushima University
Miyamoto, Hiroshi
Tokushima University
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Aoki, Rika
Tokushima Health Screening Center
Shunto, Joji
Shunto Clinic
Bando, Yoshimi
Tokushima University
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Keywords | endoscopy
gastric cancer
stomach
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Content Type |
Journal Article
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Description | Background: Autoimmune gastritis is known to be associated with neoplastic lesions but the relationship between autoimmunity and tumorigenesis have not been sufficiently clarified. The aim of this study is to assess the clinicopathological characteristics of gastric cancer cases associated with autoimmune gastritis.
Methods: A total of 24 patients diagnosed as early gastric cancer with autoimmune gastritis were registered. Chart reviews with the data including age, gender, state of Helicobacter pylori infection, comorbidity, and concomitant gastric diseases were conducted. As for the characteristics of gastric cancer, location, size, morphological type, histopathology, invasion depth, and the presence of metachronous or simultaneous lesion were assessed. These data from autoimmune gastritis group were compared with those from 301 patients of early gastric cancer as a control group. Results: The gastric cancer associated with autoimmune gastritis was located in the upper, middle, and lower parts in 28.1%, 53.1%, and 18.8%, respectively. The morphological types are as follows: 0-I, 9.4%; 0-IIa, 28.1%; 0-IIb, 15.6%; 0-IIc, 46.9%; and 0-III, 0.0%. The mean tumor size was 21.8 mm. While 90.6% were confined to the mucosa, 9.4% showed submucosal invasion. The histological classifications are as follows: tub1, 50.0%; tub2, 15.6%; pap, 21.9%; sig, 9.4%; and por, 3.1%. More numbers of female, protruded types, larger tumor size, papillary tumor, and that in the upper location were observed in autoimmune gastritis group compared to control group. Conclusion: Early gastric cancer associated with autoimmune gastritis demonstrated different characteristics from those without autoimmune gastritis including variety of tumor morphologies and histological types with female dominancy. |
Journal Title |
JGH Open
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ISSN | 23979070
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Publisher | Journal of Gastroenterology and Hepatology Foundation|John Wiley & Sons Australia
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Volume | 5
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Issue | 10
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Start Page | 1210
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End Page | 1215
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Published Date | 2021-09-16
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Rights | This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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DOI (Published Version) | |
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language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
University Hospital
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