ID | 115993 |
Title Alternative | Dynamic FDG PET/CT in MSLs
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Author |
Shinya, Takayoshi
Tokushima University|German Cancer Research Centre|Kawasaki Medical School
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Otomi, Yoichi
Tokushima University
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Nishisho, Toshihiko
Tokushima University
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Beuthien-Baumann, Bettina
German Cancer Research Centre
Irahara, Saho
Tokushima University
Kubo, Michiko
Tokushima University
Otsuka, Hideki
Tokushima University
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Bando, Yoshimi
Tokushima University
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Sairyo, Koichi
Tokushima University
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Keywords | bone and soft tissue tumors
dynamic scan
musculoskeletal lesion
positron emission tomography computed tomography
sarcoma
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Content Type |
Journal Article
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Description | We aimed to assess the differential diagnostic efficacy of dynamic F-18 fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) and to evaluate the appropriate scan timings for diagnosis of musculoskeletal lesions (MSLs). Dynamic scans (5–15 [phase 1], 15–25 [phase 2], and 25–35 [phase 3] min after F-18 FDG injection) and dual-time-point scans (1 and 2 h after injection) were acquired for 23 MSLs [4 benign MSLs (BMSLs). 10 primary malignant musculoskeletal tumors (PMMSTs), and 9 metastatic musculoskeletal tumors (MMSTs)]. We compared the maximum standardized uptake values (SUVmax) and corresponding retention indices for dynamic (RI-SUVdyn) and dual-time-point (RI-SUVdual) scans and evaluated diagnostic efficacy using receiver operating characteristic (ROC) curve analyses. The SUVmax gradually decreased or was almost identical with minimal fluctuation in 3 BMSLs and 1 PMMST. SUVmax increased over time after phase 2 in 18 malignant MSLs (MMSLs). There were significant differences in SUVmax (for all time phases) and RI-SUV dual between BMSLs and MMSLs and between PMMSTs and MMSTs. In the ROC analyses, the areas under the curve for SUV in phases 2 and 3 were highest for differentiating BMSLs from MMSLs and PMMSTs from MMSTs, respectively. Dynamic F-18 FDG PET/CT is valuable for diagnosis of musculoskeletal lesions.
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Journal Title |
The Journal of Medical Investigation
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ISSN | 13496867
13431420
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NCID | AA11166929
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Publisher | Tokushima University Faculty of Medicine
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Volume | 68
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Issue | 1-2
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Start Page | 96
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End Page | 104
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Sort Key | 96
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Published Date | 2021-02
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
University Hospital
Medical Sciences
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