ID | 110236 |
Title Transcription | コウリン ケッショウ ト シン ケッカン シッカン
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Title Alternative | Hyperphosphatemia and cardiovascular disease
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Author |
Shuto, Emi
Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
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Taketani, Yutaka
Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Tokushima University Educator and Researcher Directory
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Sakai, Tohru
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
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Takeda, Eiji
Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
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Keywords | hyperphosphatemia
cardiovascular disease
endothelial cell
oxidative stress
vascular calcification
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Content Type |
Journal Article
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Description | Hyperphosphatemia has been known as a risk factor for cardiovascular disease particularly inchronic kidney disease patients. Hyperphosphatemia can be involved in the calcification of vascularsmooth muscle cells, resulting in M¨onkeberg medial calcific sclerosis which is a type of arteriosclerosis.However, it has not been clarified whether hyperphosphatemia can deteriorate endothelialfunction and can be a risk factor of atherosclerosis. Our recent study demonstrated that hyperphosphatemiaincreased oxidative stress and decreased nitric oxide production in endothelial cells.In addition, hyperphosphatemia attenuated endothelium-dependent vasodilation reaction. Theseobservations suggest that hyperphosphatemia may cause endothelial dysfunction, and be an importantfactor for progression of atherosclerosis as well as vascular calcification. Positive associationbetween hyperphosphatemia and cardiovascular disease may be explained by the dual harmfuleffects of phosphorus on the vessels.
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Journal Title |
四国医学雑誌
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ISSN | 00373699
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NCID | AN00102041
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Publisher | 徳島医学会
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Volume | 64
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Issue | 3-4
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Start Page | 114
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End Page | 116
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Sort Key | 114
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Published Date | 2008-08-25
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FullText File | |
language |
jpn
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TextVersion |
Publisher
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departments |
Medical Sciences
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