ID | 79137 |
Author |
Teshigawara, Kiyoshi
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School|Division of Biofunctional Evaluation Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama
Hosaka, Toshio
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamaguchi, Miwa
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
KAKEN Search Researchers
Terada, Eri
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Kisyuku, Yuka
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Fukunaga, Keiko
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Hirata, Yohko
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Jambaldorj, Bayasgalan
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Harada, Nagakatsu
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
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Sakai, Tohru
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Tokushima University Educator and Researcher Directory
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Nakaya, Yutaka
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Tokushima University Educator and Researcher Directory
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|
Keywords | HBA
hyperlipidemia
TNFα
MCP1
|
Content Type |
Journal Article
|
Description | Hyperbaric air (HBA) is used to improve healing of wounds including diabetic
ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus. |
Journal Title |
The journal of medical investigation : JMI
|
ISSN | 13431420
|
NCID | AA11166929
|
Volume | 57
|
Issue | 3-4
|
Start Page | 224
|
End Page | 231
|
Sort Key | 224
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Published Date | 2010-08
|
Remark | The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
departments |
Medical Sciences
|