| ID | 119290 |
| Author |
Ogasa, Chie
Tokushima University
Kayano, Kimika
Tokushima University
Namba, Kosuke
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
|
| Keywords | tert-butylation
amino acids
tert-butyl esters
tert-butyl ethers
bis(trifluoromethanesulfonyl)imide
tert-butylation reaction
free amino acid
tert-butyl ester
tert-butyl ether
|
| Content Type |
Journal Article
|
| Description | A simple and safe tert-butylation reaction was developed. Treatment of various free amino acids with 1.1 equiv of bis(trifluoromethanesulfonyl)imide in tert-butyl acetate directly afforded tert-butyl esters with free amino groups quickly and in good yields. In addition, various carboxylic acids and alcohols without amino groups were converted to tert-butyl esters and ethers in high yields with small catalytic amounts of bis(trifluoromethanesulfonyl)imide. All tert-butylation reactions of free amino acids, carboxylic acids, and alcohols proceeded much faster and in high yields compared to conventional methods.
|
| Journal Title |
Synlett
|
| ISSN | 09365214
14372096
|
| NCID | AA10731110
|
| Publisher | Georg Thieme Verlag
|
| Volume | 35
|
| Issue | 2
|
| Start Page | 235
|
| End Page | 239
|
| Published Date | 2023-10-09
|
| Remark | 論文本文は2024-10-09以降公開予定
|
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| language |
eng
|
| TextVersion |
その他
|
| departments |
Pharmaceutical Sciences
|
