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ID 116889
Title Alternative
雌ラットにおいて生殖腺の状態とエストロゲン環境が視床下部オキシトシン遺伝子発現および血清オキシトシンレベルに及ぼす影響
Author
Tokui, Takako Tokushima University
Yanagihara, Rie Tokushima University
Kamada, Shuhei Tokushima University
Takeda, Asuka Tokushima University
Imaizumi, Junki Tokushima University
Keywords
Oxytocin
Oxytocin receptor
Hypothalamus
Estradiol
Ovariectomy
Content Type
Thesis or Dissertation
Description
Oxytocin (OT) and its receptor (OTR) play various roles in the central and peripheral regulation of appetite and body weight. Previously, we have shown that the administration of OT markedly decreased appetite and body weight gain in ovariectomized (OVX) obese rats. In addition, recent studies have shown that the endogenous OT system is also affected by endogenous or exogenous estrogen. In this study, we showed that ovariectomy decreased rats' hypothalamic OT/OTR mRNA and serum OT levels, but did not affect their visceral fat OTR mRNA levels. The chronic administration of estradiol (E2) abrogated these ovariectomy-induced changes; i.e., it increased the rats' hypothalamic OT/OTR mRNA and serum OT levels, and may be associated with reductions in food intake and body weight gain. In addition, acute E2 administration increased the rats' hypothalamic OTR mRNA and serum OT levels, but did not affect their hypothalamic OT mRNA levels. Taken together, these results suggest that endogenous OT and/or OTR expression might be positively regulated by E2 and that the suppressive effects of E2 on appetite and body weight gain might be mediated, at least in part, by the OT system. Thus, we consider that OT might be a target hormone to pursue subsequent interventions of menopause for menopause-induced metabolic disorders.
Journal Title
Hormones and Behavior
ISSN
0018506X
NCID
AA00665370
AA11539414
Publisher
Elsevier
Volume
133
Start Page
105005
Published Date
2021-06-08
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Takako Tokuiの学位論文として提出され,学位審査・授与の対象となっている。
Rights
© 2021 Elsevier Inc.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3592号
Diploma Number
甲医第1521号
Granted Date
2022-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences