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ID 118841
Author
Hashimoto, Kentaro Tokushima University
Fujiwara, Tatsuya Tokushima University
Sun, Chunzhao Tokushima University
Kuwano, Satoru Kyoto University
Keywords
asymmetric reaction
benzoin reaction
density functional theory calculation
N-heterocyclic carbene
organocatalysis
Content Type
Journal Article
Description
A remote electronic effect of chiral aminoindanol-derived N-heterocyclic carbene catalyst on an asymmetric benzoin reaction was investigated. The catalyst bearing remote electron-withdrawing substituents increased enantioselectivity of the reaction at the cost of the reaction rate. DFT calculations rationalized the increased enantioselectivity.
Journal Title
Chemistry- A European Journal
ISSN
15213765
NCID
AA11076269
Publisher
Wiley-VCH
Volume
29
Issue
38
Start Page
e202300858
Published Date
2023-04-17
Rights
This is the peer reviewed version of the following article: Inokuma, Tsubasa, Hashimoto, Kentaro, Fujiwara, Tatsuya, Sun, Chunzhao, Kuwano, Satoru, Yamada, Ken-ichi, Chem. Eur. J. 2023, 29, 38, e202300858., which has been published in final form at https://doi.org/10.1002/chem.202300858. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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DOI (Published Version)
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language
eng
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departments
Pharmaceutical Sciences