ID | 106358 |
Author |
Okada, Tsuyoshi
Department of Anesthesia, Takamatsu Red Cross Hospital
Kawahito, Shinji
Department of Anesthesiology, Tokushima University Hospital
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Matsuhisa, Munehide
Diabetes Therapeutics and Research Center, the University of Tokushima
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Kitahata, Hiroshi
Department of Dental Anesthesiology, Tokushima University Hospital
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Shimada, Mitsuo
Department of Digestive and Pediatric Surgery, Tokushima University Hospital
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Oshita, Shuzo
Department of Anesthesiology, Tokushima University Hospital
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Keywords | continuous blood glucose monitoring
intensive insulin therapy
liver transplantation
glucose toxicity
artificial endocrine pancreas
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Content Type |
Journal Article
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Description | Background : The purpose of this study was to evaluate the usefulness of the closed-loop system (STG-22 ; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose in patients undergoing liver transplantation. Methods : Sixteen patients undergoing livingdonor liver transplantation were enrolled in this study. Glucose levels were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual insulin group, n=8) or a programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n=8). The target glucose level range was set at 80-150 mg/dl. Results : The mean and SD of blood glucose concentration during surgery (Glu-Ave and Glu-SD, respectively) for the programmed insulin group were lower than for the manual insulin group. The coefficient of variability (Glu-CV=Glu-SD×100 /Glu-Ave) for the programmed insulin group was also lower than for the manual insulin group (20.1±4.9% vs. 26.9±6.1% ; mean±SD). No hypoglycemia was detected in either group. Conclusion : The STG-22 closed-loop system is effective for maintaining strict blood glucose control during liver transplantation with minimal variability in blood glucose concentration.
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Journal Title |
The journal of medical investigation : JMI
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ISSN | 13431420
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NCID | AA11166929
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Volume | 60
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Issue | 3-4
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Start Page | 205
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End Page | 212
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Sort Key | 205
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Published Date | 2013-08
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EDB ID | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
University Hospital
Institute of Advanced Medical Sciences
Oral Sciences
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