| ID | 49311 |
| Title Transcription | マッショウ タンカクキュウ サイボウ オ モチイタ マッショウ ドウミャク ヘイソクショウ ニ タイスル アラタナ ケッカン シンセイ リョウホウ ノ ココロミ
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| Title Alternative | Peripheral blood-derived mononuclear cell implantation for therapeutic angiogenesis in patients with peripheral arterial disease
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| Author |
Iwase, Takashi
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
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Kurobe, Hirotsugu
Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
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Yagi, Shusuke
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Tokushima University Educator and Researcher Directory
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Hara, Tomoko
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Choraku, Masahito
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Fujimura, Mitsunori
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Ozaki, Shuji
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Akaike, Masashi
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
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Abe, Masahiro
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
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Masuda, Yutaka
Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
Azuma, Hiroyuki
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Matsumoto, Toshio
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
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Kitagawa, Tetsuya
Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
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| Keywords | peripheral arterial disease
mononuclear cell
cell therapy
therapeutic angiogenesis
|
| Content Type |
Journal Article
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| Description | Earlier studies have shown that bone marrow-derived mononuclear cell（BM-MNC）implantation induces therapeutic angiogenesis in patients with peripheral arterial disease（PAD）. However, the invasiveness of bone marrow collection limits clinical application of BM-MNC implantation.We performed peripheral blood-derived mononuclear cell（PB-MNC）implantation in ischemic limbs of five patients with PAD. After implantation, clinical symptoms such as rest pain and numbness were relieved in four patients. Maximal walking distance markedly increased from 160 m to 915 m in one patient. Non-healing ulcers were cured after repeated cell implantation in one patient with Burger disease. There was no adverse event. These findings suggest that PB-MNC implantation is a safe and noninvasive strategy for therapeutic angiogenesis for the treatment of severe PAD.
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| Journal Title |
四国医学雑誌
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| ISSN | 00373699
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| NCID | AN00102041
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| Publisher | 徳島医学会
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| Volume | 62
|
| Issue | 3-4
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| Start Page | 137
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| End Page | 141
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| Sort Key | 137
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| Published Date | 2006-08-25
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| Remark | |
| EDB ID | |
| FullText File | |
| language |
jpn
|
| departments |
Medical Sciences
Institute of Advanced Medical Sciences
University Hospital
|
