ID | 110246 |
Title Transcription | キソ カラ リンショウ エ MR オ モチイタ タイシャ キノウ カシカ ノ サイゼンセン
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Title Alternative | Development of the visualization technique of metabolites functions using magnetic resonance imaging and spectroscopy
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Author |
Kubo, Hitoshi
Department of Medical Imaging, Institute of Health Biosciences, the University of Tokushima Graduate School
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Harada, Masahumi
Department of Medical Imaging, Institute of Health Biosciences, the University of Tokushima Graduate School
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Abe, Takamasa
Biotools Group, Oxford Instruments, Co., Ltd
Nishitani, Hiromu
Department of Radiology, Institute of Health Biosciences, the University of Tokushima Graduate School
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Keywords | magnetic resonance imaging and spectroscopy
metabolites function
molecular imaging
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Content Type |
Journal Article
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Description | Medical imaging plays an essential role in the clinical settings in Japan.Especially, magnetic resonance imaging(MRI)that measure1H behavior is widely acceptedas indispensable apparatus for daily clinical activities and researches as both morphological andfunctional imaging.Recently, measurement techniques of other nuclides such as13C,18F and31P are being developedand trying to be applied in in vivo. Of them,13C is the most suitable nuclide to observemetabolites functions of cells or organs and has possibilities to visualize these functions in in vivothough the sensitivity is quite low in comparison with1H. Development of the technique to increasesensitivity is needed to apply in clinical settings and some methods are evaluated now.Using13C enriched chemicals administrate to human is tried to observe metabolites function in invivo with MR Spectroscopy. Hyperpolarized technique that induces significantly increasing signalsof13C is developed as next generation method and exploited in in vivo imaging of animals tovisualize metabolites functions.We should develop and practice these new techniques to visualize metabolites functions in invivo and it may be beyond the conventional diagnostic imaging techniques. It may induce newdiagnostic imaging technique using physiological and biochemical approach in clinical settings.
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Journal Title |
四国医学雑誌
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ISSN | 00373699
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NCID | AN00102041
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Publisher | 徳島医学会
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Volume | 64
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Issue | 5-6
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Start Page | 170
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End Page | 174
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Sort Key | 170
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Published Date | 2008-12-20
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FullText File | |
language |
jpn
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TextVersion |
Publisher
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departments |
Medical Sciences
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