ID | 110096 |
Title Alternative | 知覚神経節内の神経伝達物質による痛み情報伝達
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Author |
Omoto, Katsuhiro
Tokushima University
Maruhama, Kotaro
Okayama University
Terayama, Ryuji
Okayama University
Yamamoto, Yumiko
Okayama University
Matsushita, Osamu
Okayama University
Sugimoto, Tomosada
Okayama University
Oguma, Keiji
Okayama University
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Keywords | Botulinum toxin
mechanical allodynia
dorsal root ganglion
transmitter release
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Content Type |
Thesis or Dissertation
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Description | Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.
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Journal Title |
Toxins
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ISSN | 20726651
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Publisher | MDPI
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Volume | 7
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Issue | 8
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Start Page | 2906
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End Page | 2917
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Published Date | 2015-08-04
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Remark | 内容要旨・審査要旨・論文本文:
内容要旨:LID201704251022.pdf 審査要旨:LID201704251023.pdf 論文本文:LID201704251024.pdf 本論文は, 著者Katsuhiro Omotoの学位論文として提出され, 学位審査・授与の対象となっている。 |
Rights | Copyright: © 2015 Omoto et al ; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3075号
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Diploma Number | 甲口第418号
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Granted Date | 2017-03-23
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Degree Name |
Doctor of Dental Science
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Grantor |
Tokushima University
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departments |
Oral Sciences
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