ID 110843
著者
カメザキ, チヒロ Kyoto Pharmaceutical University
ナカシマ, アミ Kyoto Pharmaceutical University
ヤマダ, アサコ Kyoto Pharmaceutical University
ウエニシ, サチコ Kyoto Pharmaceutical University
イシバシ, ヒロシ Kyoto Pharmaceutical University
シブヤ, ナツミ Department of Pharmaceutical Health Chemistry, Institute of Biomedical Sciences, Tokushima University, Graduate School
ハマ, ススム Kyoto Pharmaceutical University
ホソイ, シンゾウ Kyoto Pharmaceutical University
ヤマシタ, エイジ AstaReal Co., Ltd.
小暮, 健太朗 Kyoto Pharmaceutical University|Department of Pharmaceutical Health Chemistry, Institute of Biomedical Sciences, Tokushima University, Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
astaxanthin
vitamin E
tocotrienol
intermolecular interaction
synergistic activity
資料タイプ
学術雑誌論文
抄録
Astaxanthin and vitamin E are both effective antioxidants that are frequently used in cosmetics, as food additives, and in to prevent oxidative damage. A combination of astaxanthin and vitamin E would be expected to show an additive anntioxidative effect. In this study, liposomes co-encapsulating astaxanthin and the vitamin E derivatives α-tocopherol (α-T) or tocotrienols (T3) were prepared, and the antioxidative activity of these liposomes toward singlet oxygen and hydroxyl radical was evaluated in vitro. Liposomes co-encapsulating astaxanthin and α-T showed no additive anntioxidative effect, while the actual scavenging activity of liposomes co-encapsulating astaxanthin and T3 was higher than the calculated additive activity. To clarify why this synergistic effect occurs, the most stable structure of astaxanthin in the presence of α-T or α-T3 was calculated. Only α-T3 was predicted to form hydrogen bonding with astaxanthin, and the astaxanthin polyene chain would partially interact with the α-T3 triene chain, which could explain why there was a synergistic effect between astaxanthin and T3 but not α-T. In conclusion, co-encapsulation of astaxanthin and T3 induces synergistic scavenging activity by intermolecular interactions between the two antioxidants.
掲載誌名
Journal of Clinical Biochemistry and Nutrition
ISSN
09120009
18805086
cat書誌ID
AA10710201
AA12091064
出版者
Society for Free Radical Research Japan
59
2
開始ページ
100
終了ページ
106
並び順
100
発行日
2016-09-01
備考
© 2016 Society for Free Radical Research Japan
EDB ID
317555
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系