ID 63019
著者
Akiyama, Jun 徳島大学
Ogasa, Hiroshi 徳島大学
Hirata, Yoshiko 徳島大学
Yamashita, Kohei 徳島大学
Shibagaki, Haruka 徳島大学
Tanaka, Fumika 徳島大学
Sakanashi, Yoko 徳島大学
キーワード
econazole
calcium
cytotoxicity
lymphocyte
資料タイプ
紀要論文
抄録
Econazole, one of azole antifungals, is proven to exhibit an inhibitory action on Mycobaterium
tuberculosis and its multidrug-resistant strains under in vitro and ex vivo conditions. However, econazole has been used as a pharmacological tool for inhibiting capacitative Ca2+ influx and exerts multiple effects on cellular Ca2+ circumstance. Therefore, to suggest the toxic effect of econazole at therapeutic concentrations, we have tested on the effect on membrane Ca2+ transport in rat thymocytes by using a flow cytometer with Fluo-3, an indicator of intracellular Ca2+. Econazole at concentrations of 1-3 μM increased membrane Ca2+ permeability and inhibited capacitative Ca2+ influx without affecting passive Ca2+ influx, Ca2+ release from intracellular Ca2+
store sites, and membrane Ca2+ pump. Econazole at 0.3 μM, a therapeutic concentration against tuberculosis caused by multidrug-resistant and latent M. tuberculosis, did not affect membrane Ca2+ transport. It may be suggested that econazole at therapeutic concentrations exerts no side effect related to Ca2+.
出版者
徳島大学総合科学部
ISSN
09146385
cat書誌ID
AN10065859
掲載誌名
徳島大学総合科学部自然科学研究 = Natural Science Research, The University of Tokushima
23
1
開始ページ
1
終了ページ
6
並び順
1
発行日
2009-03-25
EDB ID
186250
フルテキストファイル
言語
eng
部局
生物資源系