ID 83629
著者
ドイ トシオ Department of Laboratory Medicine, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
mesangial cell
proliferation
Gas 6
growth factor
vitamin D analog
資料タイプ
学術雑誌論文
抄録
Mesangial cell proliferation is a general characteristic of a variety of glomerular diseases. Therefore, an understanding of the regulatory mechanism is important for treatment of glomerular diseases. The present review shows that the growth arrest gene 6 (Gas 6) is a new autocrine growth factor of mesangial cells and that warfarin inhibits mesangial cell proliferation by inhibiting the γ-carboxylation of Gas 6 in vitro and in vivo. The present findings also show that a vitamin D analog (22-oxa-calcitriol) is a new growth regulator of mesangial cells in vitro and in vivo. These findings indicate that these compounds have considerable potential for therapeutic use in the treatment of progressive glomerular disease.
ISSN
13431420
cat書誌ID
AA11166929
掲載誌名
The journal of medical investigation : JMI
48
1-2
開始ページ
1
終了ページ
4
並び順
1
備考
フルテキストファイル
言語
eng
部局
医学系