ID | 117602 |
タイトル別表記 | Intraplaque Microlumen and Atherosclerosis
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著者 | |
キーワード | Coronary plaque
Inflammatory molecules
Microluminal structures
Optical coherence tomography
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資料タイプ |
学術雑誌論文
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抄録 | Background: Coronary intraplaque microluminal structures (MS) are associated with plaque vulnerability, and the inward progression of vascular inflammation from the adventitia towards the media and intima has also been demonstrated. Therefore, in the present study we investigated the relationships among MS, local inflammation in adjacent epicardial adipose tissue (EAT), and coronary plaque characteristics.
Methods and Results: Optical coherence tomography (OCT) revealed MS in the left anterior descending coronary artery in 10 fresh cadaveric hearts. We sampled 30 lesions and subdivided them based on the presence of MS: MS (+) group (n=19) and MS (−) group (n=11). We measured inflammatory molecule levels in the adjacent EAT and percentage lipid volume assessed by integrated backscatter intravascular ultrasound in each lesion. The expression levels of vascular endothelial growth factor B and C-C motif chemokine ligand 2 were significantly higher in the MS (+) group than in the MS (−) group (0.9±0.7 vs. 0.2±0.2 arbitrary units (AU), P=0.04 and 1.5±0.5 vs. 0.6±0.7 AU, P=0.02, respectively). Percentage lipid volume was significantly higher in the MS (+) group than in the MS (−) group (38.7±16.5 vs. 23.7±10.9%, P=0.03). Conclusions: Intraplaque MS observed on OCT were associated with lipid-rich plaques and local inflammation in the adjacent EAT. Collectively, these results suggest that local inflammation in the EAT is associated with coronary plaque vulnerability via MS. |
掲載誌名 |
Circulation Journal
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ISSN | 13474820
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出版者 | The Japanese Circulation Society
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巻 | 87
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号 | 2
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開始ページ | 329
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終了ページ | 335
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発行日 | 2023-01-25
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権利情報 | This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/
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言語 |
eng
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著者版フラグ |
出版社版
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部局 |
病院
医学系
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