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ID 117925
著者
Jin, Shengjian Tokushima University
キーワード
head and neck squamous cell carcinoma
deubiquitination
ubiquitination
資料タイプ
学術雑誌論文
抄録
Ubiquitination and deubiquitination are two popular ways for the post-translational modification of proteins. These two modifications affect intracellular localization, stability, and function of target proteins. The process of deubiquitination is involved in histone modification, cell cycle regulation, cell differentiation, apoptosis, endocytosis, autophagy, and DNA repair after damage. Moreover, it is involved in the processes of carcinogenesis and cancer development. In this review, we discuss these issues in understanding deubiquitinating enzyme (DUB) function in head and neck squamous cell carcinoma (HNSCC), and their potential therapeutic strategies for HNSCC patients are also discussed.
掲載誌名
International Journal of Molecular Sciences
ISSN
14220067
出版者
MDPI
24
1
開始ページ
552
発行日
2022-12-29
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
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出版社版
部局
歯学系