ID | 118935 |
著者 |
Nawaz, Allah
University of Toyama|Harvard Medical School
Bilal, Muhammad
University of Toyama
Fujisaka, Shiho
University of Toyama
Kado, Tomonobu
University of Toyama
Aslam, Muhammad Rahil
University of Toyama
Ahmed, Saeed
Rawalpindi Medical University
Okabe, Keisuke
University of Toyama
Igarashi, Yoshiko
University of Toyama
Watanabe, Yoshiyuki
University of Toyama
Kuwano, Takahide
University of Toyama
Nishimura, Ayumi
University of Toyama
Nishida, Yasuhiro
University of Toyama
Yamamoto, Seiji
University of Toyama
Sasahara, Masakiyo
University of Toyama
Imura, Johji
University of Toyama
Mori, Hisashi
University of Toyama
Matzuk, Martin M.
Baylor College of Medicine
Kudo, Fujimi
Chiba University
Manabe, Ichiro
Chiba University
Nakagawa, Takashi
University of Toyama
Oishi, Yumiko
Nippon Medical School
Tobe, Kazuyuki
University of Toyama
|
資料タイプ |
学術雑誌論文
|
抄録 | Muscle regeneration requires the coordination of muscle stem cells, mesenchymal fibro-adipogenic progenitors (FAPs), and macrophages. How macrophages regulate the paracrine secretion of FAPs during the recovery process remains elusive. Herein, we systemically investigated the communication between CD206+ M2-like macrophages and FAPs during the recovery process using a transgenic mouse model. Depletion of CD206+ M2-like macrophages or deletion of CD206+ M2-like macrophages-specific TGF-β1 gene induces myogenesis and muscle regeneration. We show that depletion of CD206+ M2-like macrophages activates FAPs and activated FAPs secrete follistatin, a promyogenic factor, thereby boosting the recovery process. Conversely, deletion of the FAP-specific follistatin gene results in impaired muscle stem cell function, enhanced fibrosis, and delayed muscle regeneration. Mechanistically, CD206+ M2-like macrophages inhibit the secretion of FAP-derived follistatin via TGF-β signaling. Here we show that CD206+ M2-like macrophages constitute a microenvironment for FAPs and may regulate the myogenic potential of muscle stem/satellite cells.
|
掲載誌名 |
Nature Communications
|
ISSN | 20411723
|
cat書誌ID | AA12645905
|
出版者 | Springer Nature
|
巻 | 13
|
開始ページ | 7058
|
発行日 | 2022-11-21
|
権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
|
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
|
著者版フラグ |
出版社版
|
部局 |
医学系
|