ID | 111009 |
タイトル別表記 | 年齢に応じた血中活性型ビタミンD濃度, 腎Cyp27b1およびCyp24a1発現に対する食餌性リン反応性の変化には腎α-Klotho遺伝子発現が関連する
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著者 |
吉川, 亮平
徳島大学大学院栄養生命科学教育部(人間栄養科学専攻)
Nakahashi, Otoki
University of Tokushima|Tokushima Bunri University
Kagawa, Tomohiro
University of Tokushima
Tajiri, Mari
University of Tokushima
Nakao, Mari
University of Tokushima
Fukuda, Shiori
University of Tokushima
新井, 英一
The University of Shizuoka
Iwano, Masayuki
University of Fukui
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キーワード | α-Klotho
age-related change
vitamin D metabolism
inorganic phosphate
mice
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資料タイプ |
学位論文
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抄録 | In this study, we investigated the relationship between age-related changes in renal α-Klotho gene expression, vitamin D metabolism and the responsiveness of dietary phosphate in 1, 2 and 13 month-old mice fed a high phosphate (phosphate 1.2%) diet or low phosphate (phosphate 0.02%) diet for 5 days. We found that 1,25-dihydroxyvitamin D levels in plasma were significantly lower in the high phosphate group than the low phosphate group for 1 and 2 month-old mice, but not 13 month-old mice. In addition, in the high phosphate group plasma 1,25-dihydroxyvitamin D levels were decreased in 2 month-old mice relative to 1 month-old mice, but 13 month-old mice had higher levels than 2 month-old mice. In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Interestingly, renal α-Klotho mRNA and protein levels were significant change with age. Furthermore, α-Klotho mRNA expression showed a significant negative correlation with plasma 1,25-dihydroxyvitamin D levels in the high phosphate group. Our results suggest that age-related alterations in renal α-Klotho expression could affect the responsiveness of dietary phosphate to vitamin D metabolism.
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掲載誌名 |
Journal of Clinical Biochemistry and Nutrition
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ISSN | 18805086
09120009
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cat書誌ID | AA10710201
AA12091064
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出版者 | SOCIETY FOR FREE RADICAL RESEARCH JAPAN
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巻 | 62
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号 | 1
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開始ページ | 68
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終了ページ | 74
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発行日 | 2018-01-01
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は, 著者Ryouhei Yoshikawaの学位論文として提出され, 学位審査・授与の対象となっている。 |
権利情報 | © 2018 Society for Free Radical Research Japan
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3119号
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学位記番号 | 甲栄第245号
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学位授与年月日 | 2017-10-26
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学位名 |
博士(栄養学)
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学位授与機関 |
徳島大学
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部局 |
医学系
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