ID | 118316 |
タイトル別表記 | 液性因子および細胞性因子が成長期におけるリン誘導性の血管石灰化を抑制する
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著者 |
Okumura, Yosuke
Tokushima University
Adachi, Yuichiro
Tokushima University
Mori, Yuki
Tokushima University
Sakai, Maiko
Tokushima University
大西, 康太
Tokushima University
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キーワード | chronic kidney disease
hyperphosphatemia
fetuin-A
pyrophosphate
alkaline phosphatase
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資料タイプ |
学位論文
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抄録 | Hyperphosphatemia is an independent and non-classical risk factor of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). Increased levels of extracellular inorganic phosphate (Pi) are known to directly induce vascular calcification, but the detailed underlying mechanism has not been clarified. Although serum Pi levels during the growth period are as high as those observed in hyperphosphatemia in adult CKD, vascular calcification does not usually occur during growth. Here, we have examined whether the defence system against Pi-induced vascular calcification can exist during the growth period using mice model. We found that calcification propensity of young serum (aged 3 weeks) was significantly lower than that of adult serum (10 months), possibly due to high fetuin-A levels. In addition, when the aorta was cultured in high Pi medium in vitro, obvious calcification was observed in the adult aorta but not in the young aorta. Furthermore, culture in high Pi medium increased the mRNA level of tissue-nonspecific alkaline phosphatase (TNAP), which degrades pyrophosphate, only in the adult aorta. Collectively, our findings indicate that the aorta in growing mouse may be resistant to Pi-induced vascular calcification via a mechanism in which high serum fetuin-A levels and suppressed TNAP expression.
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掲載誌名 |
Journal of Clinical Biochemistry and Nutrition
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ISSN | 18805086
09120009
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cat書誌ID | AA10710201
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出版者 | Society for Free Radical Research Japan
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巻 | 73
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号 | 3
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開始ページ | 198
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終了ページ | 204
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発行日 | 2023-11-01
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備考 | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuki Kameiの学位論文として提出され,学位審査・授与の対象となっている。 |
権利情報 | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第3735号
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学位記番号 | 甲栄第300号
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学位授与年月日 | 2023-03-24
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学位名 |
博士(栄養学)
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学位授与機関 |
徳島大学
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部局 |
医学系
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