直近一年間の累計
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ID 119108
著者
山上, 紘規 Tokushima University|Anan Medical Center 徳島大学 教育研究者総覧
Yasui, Saya Anan Medical Center
Hosoki, Minae Anan Medical Center
Hori, Taiki Tokushima University|Anan Medical Center
Kaneko, Yousuke Anan Medical Center
Mitsui, Yukari Tokushima University
乙田, 敏城 Tokushima University
キーワード
skin autofluorescence
type 2 diabetes
diabetic kidney disease
albuminuria
tubular injury
L-FABP
資料タイプ
学術雑誌論文
抄録
It has previously been unclear whether the accumulation of advanced glycation end products, which can be measured using skin autofluorescence (SAF), has a significant role in diabetic kidney disease (DKD), including glomerular injury and tubular injury. This study was therefore carried out to determine whether SAF correlates with the progression of DKD in people with type 2 diabetes (T2D). In 350 Japanese people with T2D, SAF values were measured using an AGE Reader®, and both urine albumin-to-creatinine ratio (uACR), as a biomarker of glomerular injury, and urine liver-type fatty acid-binding protein (uLFABP)-to-creatinine ratio (uL-FABPCR), as a biomarker of tubular injury, were estimated as indices of the severity of DKD. Significant associations of SAF with uACR (p < 0.01), log-transformed uACR (p < 0.001), uL-FABPCR (p < 0.001), and log-transformed uL-FABPCR (p < 0.001) were found through a simple linear regression analysis. Although SAF was positively associated with increasing uL-FABPCR (p < 0.05) and increasing log-transformed uL-FABPCR (p < 0.05), SAF had no association with increasing uACR or log-transformed uACR after adjusting for clinical confounding factors. In addition, the annual change in SAF showed a significant positive correlation with annual change in uL-FABPCR regardless of confounding factors (p = 0.026). In conclusion, SAF is positively correlated with uL-FABP but not with uACR in people with T2D. Thus, there is a possibility that SAF can serve as a novel predictor for the development of diabetic tubular injury.
掲載誌名
Biomedicines
ISSN
22279059
出版者
MDPI
11
11
開始ページ
3020
発行日
2023-11-10
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系
先端酵素学研究所